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A Study on Mouse Hepatitis Virus Receptor Genotype in the Wild Mouse

  • Nobuhisa Ohtsuka
  • Kimiyuki Tsuchiya
  • Eiichi Honda
  • Fumihiro Taguchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Whereas most of laboratory mouse strains are susceptible to mouse hepatitis virus (MHV) infection, only SJL mouse strain is resistant (Smith et al, 1984). MHV susceptible mouse strains have CEACAM1a (MHVR1) as a receptor for MHV, while SJL mice have CEACAM1b (MHVR2) (Ohtsuka and Taguchi, 1997). Although these molecules are functional receptors for MHV (Yokomori and Lai, 1992), there is a striking difference in receptor functionality between these two proteins. MHVR1 has 250∼500 times higher receptor-binding activity relative to MHVR2 as examined by a virus overlay protein blot assay and 10∼30 times higher receptor activity when expressed on cells without MHV receptor (Ohtsuka et al., 1996, Rao et al., 1997). These findings suggest that the difference in susceptibility to MHV infection between MHV-susceptible mouse strains and SJL could result from the difference in receptor functionality found between MHVR1 and MHVR2.

Keywords

Mouse Strain Receptor Functionality Rous Sarcoma Virus Wild Mouse Mouse Hepatitis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Nobuhisa Ohtsuka
    • 1
    • 3
  • Kimiyuki Tsuchiya
    • 2
  • Eiichi Honda
    • 3
  • Fumihiro Taguchi
    • 1
  1. 1.National Institute of NeuroscienceNCNPKodairaJapan
  2. 2.Department of PhysiologyMiyazaki Medical College 5200 KiharaKiyotakeJapan
  3. 3.Department of Veterinary Medicine, Faculty of AgricultureTokyo University of Agriculture and TechnologyFuchuJapan

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