A Study on Mouse Hepatitis Virus Receptor Genotype in the Wild Mouse
Whereas most of laboratory mouse strains are susceptible to mouse hepatitis virus (MHV) infection, only SJL mouse strain is resistant (Smith et al, 1984). MHV susceptible mouse strains have CEACAM1a (MHVR1) as a receptor for MHV, while SJL mice have CEACAM1b (MHVR2) (Ohtsuka and Taguchi, 1997). Although these molecules are functional receptors for MHV (Yokomori and Lai, 1992), there is a striking difference in receptor functionality between these two proteins. MHVR1 has 250∼500 times higher receptor-binding activity relative to MHVR2 as examined by a virus overlay protein blot assay and 10∼30 times higher receptor activity when expressed on cells without MHV receptor (Ohtsuka et al., 1996, Rao et al., 1997). These findings suggest that the difference in susceptibility to MHV infection between MHV-susceptible mouse strains and SJL could result from the difference in receptor functionality found between MHVR1 and MHVR2.
KeywordsMouse Strain Receptor Functionality Rous Sarcoma Virus Wild Mouse Mouse Hepatitis Virus
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