The Nidoviruses pp 213-218 | Cite as
Involvement in Fusion Activity of an Epitope in the S2 Subunit of Murine Coronavirus Spike Protein
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Abstract
The spike projecting from the virion of mouse hepatitis virus (MHV) is composed of a spike (S) glycoprotein with 180 to 200 kDa. The S protein is cleaved into N-terminal S1 and C-terminal S2 subunits. The S1 forms the globular part of the spike and the S2 its stalk portion. An important biological function of the S protein is binding to the virus receptor, which is mediated by a domain located in the N terminal 330 residues of the S1 (S1N330) (Kubo et al., 1994). Virus-cell fusion is also mediated by the S protein (Collins et al., 1982). Various regions in the S2 are involved in fusion activity. A candidate fusion peptide was reported to reside in the S2 (Luo and Weiss, 1998).
Keywords
Fusion Peptide Virus Neutralize Fusion Activity Recombinant Vaccinia Virus Fusion Inhibition
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