Abstract
Development of demyelination in the MHV system is associated with inflammatory cytokine responses in the brain. It is likely that these responses reflect the influx of T cells into the brain following infection. Previous work has described a central role for CD4+ T cells in viral clearance and subsequent demyelination (Lane, Liu et al. 1999; Lane, Liu et al. 2000; Wu, Dandekar et al. 2000). While CD8+ T cells are necessary for viral clearance, their involvement in demyelination is less defined (Castro, Evans et al. 1994; Stevenson, Belz et al. 1999). Glial cells have also been implicated in the disease process, contributing to cytokine production in the central nervous system (Sun, Grzybicki et al. 1995; Lane, Asensio et al. 1998).
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Keywords
- Viral Clearance
- RNase Protection Assay
- Central Nervous System Inflammation
- Mouse Hepatitis Virus
- Spike Protein
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2001 Springer Science+Business Media New York
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Rempel, J.D., Buchmeier, M.J. (2001). Analysis of CNS Inflammatory Responses to MHV. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_12
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DOI: https://doi.org/10.1007/978-1-4615-1325-4_12
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