Advertisement

Genes, Environment and Diabetes in Canadian Aboriginal Communities

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 498)

Abstract

Mortality rates among aboriginal Canadians are higher than those in the general Canadian population1–3. This excess mortality is related to the increased risk of death from alcoholism, homicide, suicide and pneumonia in many native groups1–3. In contrast, some native groups have a markedly lower incidence of heart disease and certain types of cancer compared with the general Canadian population4–5.However, it has been suggested that the rapid cultural changes currently faced by many Canadian native groups may accelerate the development of “diseases of westernization”, such as atherosclerosis and related conditions 5–8. One factor that is inextricably linked to the anticipated rise of atherosclerosis in native Canadians is the emergence of diabetes mellitus as a health problem in certain native subgroups9.

Keywords

European Origin Traditional Diet Thrifty Genotype Remote Aboriginal Community Sandy Lake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. 1.
    F. Trovato. Mortality differentials in Canada 1951–1971: French, British and Indians. Cult Med Psychiatry 1988; 12: 459–477.PubMedCrossRefGoogle Scholar
  2. 2.
    Y. Mao, B.W. Moloughney, R.M. Semenciw, H.I. Morrison. Indian reserve and Indian mortality in Canada. Can J Pub Health 1992; 83: 350–353.Google Scholar
  3. 3.
    H.L. MacMillan, A.B. MacMillan, D.R. Offord, J.L. Dingle. Aboriginal health. CMAJ 1996; 155:1569–1578.Google Scholar
  4. 4.
    T.K. Young. Mortality pattern of isolated Indians in northwestern Ontario. A 10 year review. Public Health Rep 1983; 98:467–475.PubMedGoogle Scholar
  5. 5.
    T.K. Young, M.E. Moffatt, J.D. O’Neil. Cardiovascular diseases in a Canadian Arctic population. Am J Public Health 1993; 83:881–887.PubMedCrossRefGoogle Scholar
  6. 6.
    T.K. Young. Chronic diseases among Canadian Indians: towards an epidemiology of culture change. Arctic Med Res 1988; 47(1): 434–441.PubMedGoogle Scholar
  7. 7.
    T.K. Young. The Canadian north and the third world: is the analogy appropriate? Can J Pub Health 1983; 74: 239–241.Google Scholar
  8. 8.
    D. Steib, K. Davies. Health and development in the Hudson Bay/James Bay region. Arctic Med Res 1995; 54: 170–183.Google Scholar
  9. 9.
    T.K. Young, J. Reading, B. Elias, J.D. O’Neil. Type 2 diabetes mellitus in Canada’s first nations: status of an epidemic in progress. CMAJ 2000; 163: 561–566.PubMedGoogle Scholar
  10. 10.
    T.K. Young, E.J. Szathmary, S. Evers B. Wheatley. Geographical distribution of diabetes among the native population of Canada: a national survey. Soc Sci Med 1990; 129–139.Google Scholar
  11. 11.
    S.B. Harris, J. Gittelsohn, A.J.G Hanley, A. Barnie, T.M.S. Wolever, J. Gao, A.Logan, B. Zinman B. The prevalence of NIDDM and associated risk factors in native Canadians. Diabetes Care 1997; 20:185–197PubMedCrossRefGoogle Scholar
  12. 12.
    R.A. Hegele, S.B. Harris, A.J. Hanley, S. Sadikian, P.W. Connelly, B. Zinman. Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians. J Clin Endocrinol Metab 1996; 81:4334–4337.PubMedCrossRefGoogle Scholar
  13. 13.
    R.A. Hegele, P.W. Connelly, S.W. Scherer, A.J. Hanley, S.B. Harris, L.C. Tsui, B. Zinman. Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997; 82:3373–3377.PubMedCrossRefGoogle Scholar
  14. 14.
    R.A. Hegele, P.W. Connelly, S.W. Scherer, A.J. Hanley, S.B. Harris, L.C. Tsui, B. Zinman. Paraoxonase-2 G148 variant in an aboriginal Canadian girl with non-insulin-dependent diabetes. Lancet 1997; 350:785.PubMedCrossRefGoogle Scholar
  15. 15.
    R.A. Hegele, B. Zinman, A J Hanley, S. Harris, P.W. Connelly. A common mtDNA polymorphism associated with variation in plasma triglyceride concentration. Am J Hum Genet 1997; 60:1552–1555.PubMedCrossRefGoogle Scholar
  16. 16.
    R.A. Hegele, P.W. Connelly, A.J. Hanley, F. Sun, S.B. Harris, B. Zinman. Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians. Arterioscler Thromb Vasc Biol 1997; 17:1060–1066.PubMedCrossRefGoogle Scholar
  17. 17.
    R.A. Regele, P.W. Connelly, A.J. Hanley, F. Sun, S.B. Harris, B. Zinman. Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins. Arterioscler Thromb Vasc Biol 1997; 17: 2753–2758.CrossRefGoogle Scholar
  18. 18.
    R.A. Hegele, S.B. Harris, A.J. Hanley, F. Sun, P.W. Connelly, B. Zinman Angiotensinogen gene variation associated with variation in blood pressure in aboriginal Canadians. Hypertension 1997; 29:1073–1077.PubMedCrossRefGoogle Scholar
  19. 19.
    R.A. Hegele, S.B. Harris, A.J. Hanley, F. Sun, P.W. Connelly, B. Zinman. -6A promoter variant of angiotensinogen and blood pressure variation in Canadian Oji-Cree. J Hum Genet 1998;43:37–41.PubMedCrossRefGoogle Scholar
  20. 20.
    R.A. Hegele RA, Harris SB, Hanley AJ, Azouz H, Connelly PW, Zinman B. Absence of association between genetic variation of the beta 3-adrenergic receptor and metabolic phenotypes in Oji-Cree. Diabetes Care 1998; 21:851–854.PubMedCrossRefGoogle Scholar
  21. 21.
    R.A. Hegele, T.M. Wolever, A.J.Hanley, S.B. Harris, B. Zinman B Methylenetetrahydrofolate reductase gene, dietary folate, NIDDM, and atherosclerosis in Canadian Oji-Cree. Diabetes Care 1998;21:322–323.PubMedCrossRefGoogle Scholar
  22. 22.
    M.E.K. Moffatt, T.K Young, J.D. O’Neil JD. The Keewatin Health Assessment Study. Arctic Med Res 1993; 52: 18–21.PubMedGoogle Scholar
  23. 23.
    T.K. Young, Y.P. Nikitin, E.V. Shubinov, T.I. Astakhova, M.E.K. Moffatt, J.D. O’Neil. Plasma lipids in two indigenous arctic populations with low risk for cardiovascular diseases. Am JHum Biol 1995; 7:223–236.CrossRefGoogle Scholar
  24. 24.
    R.A. Hegele, T.K. Young, P.W. Connelly. Are Canadian Inuit at increased genetic risk for coronary heart disease? J Mol Med 1997; 75:364–370.PubMedCrossRefGoogle Scholar
  25. 25.
    R.A. Hegele, C. Tully, T.K. Young, P.W. Connelly. V677 mutation of methylenetetra-hydrofolate reductase and cardiovascular disease in Canadian Inuit. Lancet 1997; 349:1221–1222.PubMedCrossRefGoogle Scholar
  26. 26.
    D.R. Price, P.M. Ridker. Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective. Ann Int Med 1997; 127:895–903.PubMedGoogle Scholar
  27. 27.
    R. Guerra, J. Wang, S.M. Grundy, J.C. Cohen. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 1997; 94:4532–4537.PubMedCrossRefGoogle Scholar
  28. 28.
    J. Xia, S.W. Scherer, P.T.W. Cohen, M. Majer, R.A. Norman, W.C. Knowler, C. Bogardus, M. Prochazka A common variant in PPPIR3 contributes to insulin resistance and type-2 diabetes. Diabetes 1998; 47:1519–1524.PubMedCrossRefGoogle Scholar
  29. 29.
    A.T. Merryweather-Clarke, J.J. Pointon, J.D. Shearman, K.J.H. Robson. Global prevalence of putative haemochromatosis mutations. J Med Genet 1997; 34:275–278.PubMedCrossRefGoogle Scholar
  30. 30.
    T.M. Wolever, S. Hamad, J. Gittelsohn, J. Gao, A.J. Hanley, S.B. Harris, B. Zinman. Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community. Am J Clin Nutr 1997; 66: 1470–1477.PubMedGoogle Scholar
  31. 31.
    J. Gittelsohn, T.M. Wolever, S.B. Harris, R. Harris-Giraldo, A.J.G. Hanley, B. Zinman. Specific patterns of food consumption and preparation are associated with diabetes and obesity in a native Canadian community. JNutr 1998; 128: 541–547.Google Scholar
  32. 32.
    B. Shah, J.B. Hux. B. Zinman Increasing rates of ischemic heart disease in the native population of Ontario, Canada. Diabetes 1999; A169.Google Scholar
  33. 33.
    R.A. Hegele, H. Cao, S.B. Harris, A.J. Hanley, B. Zinman The hepatic nuclear factor-lalpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab 1999; 84:1077–82.CrossRefGoogle Scholar
  34. 34.
    R.A. Hegele, H. Cao, A.J. Hanley, B. Zinman, S.B. Harris, C.M. Anderson. Clinical utility of HNFIA genotyping for diabetes in aboriginal Canadians. Diabetes Care 2000; 23:775–778.PubMedCrossRefGoogle Scholar
  35. 35.
    J.V. Neel. The genetics of diabetes mellitus. In Early Diabetes. R. Camerini-Davalos, H.S. Cole (eds) 1970. Academic Press, Inc., Orlando, FLA, pp 3–10.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  1. 1.Blackburn Cardiovascular Genetics LaboratoryJohn P. Robarts Research InstituteLondonCanada

Personalised recommendations