Left Ventricular Diastolic Dysfunction in Diabetic or Hypertensive Subjects: Role of Collagen Alterations
Diabetes and hypertension may be associated with myocardial rather than coronary diseases as the preventing clinical abnormality1,2. An early functional alteration of the left ventricle in these states is often diastolic rather than systolic. In addition abnormalities of glucose and insulin metabolism that are less than seen in frank diabetes have recently been described for the hypertensive state3. In view of the observation that glucose intolerance in a normotensive canine model has been associated with diastolic dysfunction and interstitial fibrosis of the ventricle4 a potential role of the metabolic abnormality in the myocardial response to hypertension has been raised.
KeywordsDiastolic Function Glucose Intolerance Diabetic Heart Hypertensive Group Collagen Accumulation
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