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Potassium Channels in Cardiovascular Biology pp 177–191Cite as

Use of Transgenic and Gene-Targeted Mice to Study K+Channel Function in the Cardiovascular System

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Abstract

A large number of K+ channel genes are expressed in the mammalian heart (for reviews, see Chandy and Gutman, 1995; Deal et al., 1996; Yost, 1999). The diversity of channel expression is enhanced further by coassembly of subunits encoded by different genes to form heteromeric channels, interaction of α-subunits with β-subunits, alternative splicing of K+ channel genes, posttranslational channel modifications, and factors that control insertion and clustering of channels on the cell membrane (Po et al., 1993; Morales et al., 1995; Kim et al., 1996; London et al., 1997; Zhou et al., 1998). This marked diversity leads to a complex array of K+ currents within the heart that varies among species and changes during development.

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Author information

Authors and Affiliations

  1. Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA

    Barry London

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  1. Barry London
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Editor information

Editors and Affiliations

  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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© 2001 Springer Science+Business Media New York

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London, B. (2001). Use of Transgenic and Gene-Targeted Mice to Study K+Channel Function in the Cardiovascular System. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_11

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  • DOI: https://doi.org/10.1007/978-1-4615-1303-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5487-1

  • Online ISBN: 978-1-4615-1303-2

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