Abstract
Comparative immunology had its origin in the studies of inflammation by Elie Metchnikoff who proposed that the primary effectors of the immune response were circulating, amoeboid, phagocytic cells (Metchnikoff, 1891). In order to support this proposal, Metchnikoff reported that the bipinnaria larvae of a sea star would respond to physical injury (the introduction of rose prickles or glass rods into the larval blastocoel), to a normal infection by marine algae or to the artificial introduction of bacteria into the blastocoel with the encapsulation and phagocytosis of these foreign materials by accumulated amoeboid, phagocytic mesodermal cells. These studies were the first to demonstrate that echinoderms, and by inference according to Metchnikoff, all animals were capable of responding to inert substances, to injury and to foreign or pathogenic cells.
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References
Agrawal, A., Q.M. Eastman and D.G. Schats. 1998. Transposition mediated by RAG I and RAG2 and it implications for the evolution of the immune system. Nature 394:744
Al-Sharif, W.Z., J.O. Sunyer, J.D. Lambris and L.C. Smith. 1998. Sea urchin coelomocytes specifically express a homologue of complement component C3. Jlmmunol 160:2983.
Bentley, D. R. 1988. Structural superfamilies of the complement system. Expl Clin Immunogenet 5:69.
Campbell, R. D., S. K. Law, K. B. M. Reid and R. B. Sim. 1988. Structure, organization, and regulation of the complement genes. Ann Rev Immunol 6:161.
Coffaro, K.A. 1979. Transplantation immunity in the sea urchin. Doctoral dissertation, University of California, Santa Cruz, CA.
DiScipio, R.G. 1992. Ultrastructure and interactions of complement factors H and 1.. Jlmmunol 149:2592.
Dodds, A.W., X.-D. Ren, A.C. Willis and S.K.A. Law. 1996. The reaction mechanism of the internal thioester in the human complement component C4. Nature 379:177.
Edds, K.T. “Morphological and cytoskeletal transformation in sea urchin coelomocytes.” In Blood Cells of Marine Invertebrates: Experimental Systems in Cell Biology and Comparative Physiology, W. D. Cohen, ed. A. R. Liss, New York, NY, 1985, 53.
Fearon, D.T. 1998. The complement system and adaptive immunity. Semin Immunol 10:355.
Fearon, D.T. and R.M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science 272:50
Finke, T., J.A. Theriot, K.R. Dise, G.F. Tomaselli and P.J. Goldschmidt-Clermont. 1994. Dynamic actin structures stabilized by profilin. PNAS USA 91:1510.
Gross, P.S., W.Z. Al-Sharif, L.A. Clow and L.C. Smith. 1999. Echinoderm immunity and the evolution of the complement system. Dev Comp Immunol in press
Hanley, P. J., J.W. Hook, D.A. Raftos, A.A. Gooley, R. Trent and R.L. Raison. 1992. Hagfish humoral defense protein exhibits structural and functional homology with mammalian complement components. PNAS USA 89:7910.
Hildemann, W.H. and Dix, T.G. 1972. Transplantation reactions of tropical Australian echinoderms. Transplantation 15:624.
Hiom, K., M. Melek and M. Gellert. 1998. DNA transposition by the RAGI and RAG2 proteins: a possible source of oncogenic translocations. Cell 94:463.
Horiuchi, T., S. Kim, M. Matsumoto, I. Watanabe, S. Fujita and J.E. Volanakis. 1993. Human complement factor B: eDNA cloning, nucleotide sequencing, phenotype conversion by site-directed mutagenesis and expression. Mol Immunol 30:1587.
Hourcade, D.E., L.M. Wagner and T.J. Oglesby. 1995. Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis. J Biol Chem 270:19716.
Isaac, L. and D.E. Isenman. 1992. Structural requirements for thioester bond formation inhuman complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3. JBiol Chem 267:10062.
Ishiguro, H., D. Kobayashi, M. Suzuki, K. Titani, S. Tomonaga and Y. Kurosawa. 1992. Isolation of a hagfish gene that encodes a complement component. EMBO J 11:892.
Johnson, P.T. 1969. The coelomic elements of sea urchins (Strongylocentrotus). III. In vitro reaction to bacteria. Jlnvert Pathol 13:42.
Karp, R.D. and Hildemann, W.H. 1976. Specific allograft reactivity in the sea starDermasterias imbricata. Transplantation 22:434.
Lambris, J. D., Z. Lao, J. Pang and J. Alsenz. 1993. Third component of trout complement. cDNA cloning and conservation of functional sites. Jlmmunol. 151:6123.
Lambris, J.D., M. Mavroidis and J.O. Sunyer. Phylogeny of third component of complement, C3. In New aspects of complement structure and function. A. Erdei, ed. R. G. Landes Co., Austin, Texas. 1994, 34.
Metchnikoff, E. Lectures on the Comparative Pathology of Inflammation: Delivered at the Pasteur Institute in 1891. trans. F.A. Starling and E.H. Starling, M.D. Kegan Paul, Trench, Trubner & Co., Ltd., London 1893.
Nonaka, M., R. Fugii, T. Kaidoh, S. Natsuume-Sadai, N. Yamaguchi and M. Takahashi. 1984. Purification of a lamprey complement protein homologous to the third complement of the mammalian complement system. Jlmmunol 133:3242.
Nonaka, M. and M. Takahashi. 1992 Complete complementary DNA sequence of the 3rd component of complement of Lamprey: implication for the evolution of thioester containing proteins. Jlmmunol 148:3290.
Nonaka, M., M. Takahashi and M. Sasaki. 1994. Molecular cloning of a lamprey homologue of the mammalian MHC class III gene, complement factor B. Jlmmunol 152:2263.
Nonaka, M., K. Azumi, X. Ji, C. Namikawa-Yamada, M. Sasaki, H. Saiga, A.W. Dodds, H. Sekine, M.K. Homma, J. Matsushita, Y Endo and T. Fujita. 1999. Opsonic complement component C3 in the solitary ascidian, Halocynthia roretzi. Jlmmunol 162:387.
Nonaka, M. and K. Azumi. 1999. Opsonic complement system of the solitary ascidian, Halocynthia roretzi. Dev Comp Immunol in press.
Raftos, D.A., J.W. Hook and R.L. Raison. 1992. Complement-like protein from the phylogenetically primitive vertebrate, Eptatretus stouti, is a humoral opsonin. Comp Biochem Physiol 103B:379.
Reid, K. M. B. and Campbell, R. D. 1993. Structure and organization of complement genes. Immunol Med 20:89.
Sim, R.B. and E. Sim. 1981. Autolytic fragmentation of complement components C3 and C4 under denaturing conditions, a property shared with az macroglobulin. Biochem J 193:129.
Sim, R.B. and E. Sim. 1983. Autolytic fragmentation of complement components C3 and C4 and its relationship to covalent binding activity. Ann NYAcad Sci. 421:259.
Smith, L.C., R.J. Britten and E.H. Davidson. 1992. SpCoel I, a sea urchin profilin gene expressed specifically in coelomocytes in response to injury. Mol Bio Cell 3:403.
Smith, L.C. and E.H. Davidson. 1992. The echinoid immune system and the phylogenetic occurrence of immune mechanisms in deuterostomes. Immunol Today 13:356.
Smith, L.C. and E.H. Davidson. 1994. The echinoderm immune system: characters shared with vertebrate immune systems, and characters arising later in deuterostome phylogeny. In: Primordial Immunity: Foundations for the Vertebrate Immune System, G. Beck, E. L. Cooper, G. S. Habicht and J. J. Marchalonis, eds. Ann NYAcad Sci 712:213.
Smith, L.C., R.J. Britten and E.H. Davidson. 1995. Lipopolysaccharide activates the sea urchin immune system. Dev. Comp. Immunol. 19:217.
Smith, L.C., L. Chang, R.J. Britten and E.H. Davidson. 1996. Sea urchin genes expressed in activated coelomocytes are identified by expressed sequence tags (ESTs). Complement homologues and other putative immune response genes suggest immune system homology within the deuterostomes. J Immunol 156:593.
Smith, L.C., C.-S. Shih and S.G. Dachenhausen. 1998. Coelomocytes specifically express SpBf, a homologue of factor B, the second component in the sea urchin complement system. J Immunol 161:6784.
Smith, L.C., K. Azumi and M. Nonaka. 1999. Complement systems in invertebrates. The ancient alternative and lectin pathways. Immunopharm in press.
Sohn, R.H. and P. J. Goldschmidt-Clermont. 1994. Profilin: at the crossroads of signal transduction and the actin cytoskeleton. Bioessays 16:465.
Xu, Y. and J.E. Volanakis. 1997. Contribution of the complement control protein modules of C2 in C4b binding assessed by analysis of C2/Bf chimeras. J Immunol 158:5958.
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Smith, L.C. (2001). The Complement System in Sea Urchins. In: Beck, G., Sugumaran, M., Cooper, E.L. (eds) Phylogenetic Perspectives on the Vertebrate Immune System. Advances in Experimental Medicine and Biology, vol 484. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1291-2_35
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DOI: https://doi.org/10.1007/978-1-4615-1291-2_35
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