Abstract
In the United States, with over 60,000 chemicals in commercial use, millions of people are exposed daily to neurotoxic compounds in occupational and environmental settings (Goetz, 1985). While many of these chemicals can be handled safely with minimal risk, numerous substances pose a threat to human health, especially if adequate precautions are not taken.
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References
Agency for Toxic Substances and Disease Registry. (1993). Toxicology profile for lead. Springfield, IL:National Technical Information Service.
Antti-Poika, M. (1982). Overall prognosis of patients with diagnosed chronic organic solvent intoxication. International Archives of Occupational and Environmental Health, 51, 127–138.
Araki, S., Honma, T., Yangihara, S., & Ushio, K. (1980). Recovery of slowed nerve conduction velocity in lead-exposed workers. International Archives of Occupational and Environmental Health, 46,151–157.
Araki, S., Murata, K., & Aono, H. (1987). Central and peripheral nervous system dysfunction in workers exposed to lead, zinc, and copper. A follow-up study of visual and somatosensory evoked potentials. International Archives of Occupational and Environmental Health, 59, 177–187.
Arlien-Søborg, P., Bruhn, P., Gyldensted, C., & Melgaard, B. (1979). Chronic painters syndrome. Ada Neurologica Scandinavica, 60, 149–156.
Arlien-Søberg, P., Henriksen, L., Gade, A., Gyldensted, C., & Paulson, O. B. (1982). Cerebral blood flow in chronic toxic encephalopathy in house painters exposed to organic solvents. Ada Neurologica Scandinavica, 66, 34–41.
Arnvig, E., Grandjean, P., & Beckmann, J. (1980). Neurotoxic effects of heavy lead exposure determined with psychological tests. Toxicology Letters, 5, 399–404.
Ashby, J. A. (1980). A neurological and biochemical study of early lead poisoning. British Journal of Industrial Medicine, 37, 133–140.
Axelson, O., Hane, M., & Hogstedt, C. (1976). A case-referent study on neuropsychiatric disorders among workers exposed to solvents. Scandinavian Journal of Work Environment and Health, 2,14–20.
Baelum,J., Anderson, I., Lundqvist, G. R., Mølhave, L., Pedersen, O. F., Væth, M., & Wyon, D. P. (1985).Response of solvent- exposed printers and unexposed controls to six-hour toluene exposure.Scandinavian Journal of Work Environment and Health, 11, 271–280.
Baker, E. L., & Fine, L. J. (1986). Solvent neurotoxicity: The current evidence. Journal of Occupational Medicine, 28, 126–129.
Baker, E. L., Landrigan, P. J., & Barbour, A. G. (1979). Occupational lead poisoning in the United States:Clinical and biochemical findings related to blood lead levels. British Journal of Industrial Medicine, 36, 314–322.
Baker, E. L., Feldman, R. G., White, R. F., & Harley, J. P. (1983). The role of occupational lead exposure in the genesis of psychiatric and behavioral disturbances. Acta Psychiatrica Scandinavica, 303(Suppl.), 38’48.
Baker, E. L., Feldman, R. G., White, R. A., Harley, J. P., Niles, C. A., Dinse, G. E., & Berkey, C. S. (1984).Occupational lead neurotoxicity: A behavioral and electrophysiological evaluation. Study design and year one results. British Journal of Industrial Medicine, 41, 352–361.
Baker, E., Letz, R., Eisen, E., Pothierl, E. A., Plantamura, D. L., Larson, M., & Wolford, R. (1988).Neurobehavioral effects of solvents in construction painters. Journal of Occupational Medicine, 30,116–123.
Baloh, R. W., Spively, G. H., Brown, C. P., Morgan, D., Campion, D. S., Browdy, B. L., Valentine, J. L.,Gonick, H. C., Massey, F. J., Jr., & Culver, B. D. (1979). Subclinical effects of chronic increased lead absorption-A prospective study. II. Results of baseline neurologic testing. Journal of Occupational Medicine, 21, 490–496.
Barry, P. S. (1975). A comparison of concentrations of lead in human tissues. British Journal of Industrial Medicine, 32, 119–139.
Bleecker, M. (1995). Invited commentary: Solvent exposure as a risk factor for Alzheimer’s disease: A multiple insult hypothesis. American Journal of Epidemiology, 141, 1072–1074.
Bleecker, M. L., Bolla, K. I., Agnew, J., Schwartz, B. S., & Ford, D. P. (1991). Dose-related subclinical neurobehavioral effects of chronic exposure to low levels of organic solvents. American Journal of Industrial Medicine, 19, 715–728.
Bleecker, M. L., Lindgren, K. N., & Ford, D. P. (1997). Differential contribution of current and cumulative indices of lead dose to neuropsychological performance by age. Neurology, 48, 639–645.
Bolla, K. I., Schwartz, B. S., Agnew, J., Ford, P. D., & Bleecker, M. L. (1990). Subclinical neuropsychiatric effects of chronic low-level solvent exposure in US paint manufacturers. Journal of Occupational Medicine, 32, 671–677.
Bolla, K. I., Schwartz, B. S., Stewart, W., Rignani, J., Agnew, J., & Ford, P. (1995). Comparison of neurobehavioral function in workers exposed to a mixture of organic and inorganic lead and in workers exposed to solvents. American Journal of Industrial Medicine, 27, 231–246.
Bowler, R. M., Mergler, D., Huel, G., Harrison, R., & Cone, J. (1991). Neuropsychological impairment among former microelectronics workers. Neurotoxicology, 12, 87–104.
Braceland, F. J. (1942). Mental symptoms following carbon disulphide absorption and intoxication.Annals of Internal Medicine, 16, 246–261.
Brackbill, R., Maizlish, N., & Fischback, T. (1990). Risk of neuropsychiatric disability among painters in the United States. Scandinavian Journal of Work Environment and Health, 16, 182–188.
Bruhn, P., Arlien-Søberg, P., Gyldensted, C., & Christensen, E. L. (1981). Prognosis in chronic toxic encephalopathy: A two year follow up study in 26 house painters with occupational encephalopathy. Ada Neurologica Scandinavica, 64, 259–272.
Buchthal, F., & Behse, F. (1979). Electrophysiology and nerve biopsy in men exposed to lead. British Journal of Industrial Medicine, 36, 135–147.
Callender, T., Morrow, L., Subramanian, K., Duhon, D., & Ristovv, M. (1993). Three-dimensional brain metabolic imaging in patients with toxic encephalopathy. Environmental Research, 60, 295–319.
Calne, D., Eisen, A., McGeer, E., & Spencer, P. (1986). Alzheimer’s disease, Parkinson’s disease, and motoneurone disease: Abiotropic interaction between ageing and environment. Lancet, 8, 1067–1070.
Campara, P., D’Andrea, F., Micciolo, R., Savonitto, C., Tansella, M., & Zimmermann-Tansella, C. (1984).Psychological performance of workers with blood lead concentration below the current threshold limit value. International Archives of Occupational and Environmental Health, 53, 233–246.
Cherry, N., Waldron, H. A., Wells, G. G., Wilkinson, R. T., Wilson, H. K., & Jones, S. (1980). An investigation of the acute behavioral effects of styrene on factory workers. British Journal of Industrial Medicine, 37, 234–240.
Cherry, N., Hutchins, H., Pace, T., & Waldron, H. A. (1985). Neurobehavioral effects of repeated occupational exposure to toluene and paint solvents. British Journal of Industrial Medicine, 42,291–300.
Colvin, M., Myers, J., Nell, V., Rees, D., & Cronje, R. (1993). A cross-sectional survey of neurobehavioral effects of chronic solvent exposure on workers in a paint manufacturing plant. Environmental Research, 63, 122–132.
Condray R.,Morrow, L., Steinhauer, S., & Hodgson, M. (in press). Mood and behavioral symptoms in individuals with chronic solvent exposure. Psychiatry Research.
Cooper, W. C, & Gaffey, W. R. (1975). Mortality of lead workers. Journal of Occupational Medicine, 17,100–107.
Cooper, G. P., Suszkiw, J. B., & Manalis, R. S. (1984). Heavy metals: Effects on synaptic transmission.Neurotoxicology, 5, 247–266.
Cory-Slechta, D. A. (1996). Legacy of lead exposure: Consequences for the central nervous system.Otolaryngology, Head and Neck Surgery, 114, 224–226.
Cranmer, J. M., & Golberg, L. (Eds.). (1986). Proceedings of the workshop on neurobehavioral effects of solvents. Neurotoxicology, 7, 1–95.
Dagar, S. R., Holland, J. P., Cowley, D. S., & Dunner, D. L. (1987). Panic disorder precipitated by exposure to organic solvents in the work place. American Journal of Psychiatry, 144, 1056–1058.
Daniell, W., Stebbins, A., O’Donnell, J., Horstman, S. W., & Rosenstock, L. (1993). Neuropsychological performance and solvent exposure among car body repair shop workers. British Journal of Industrial Medicine, 50, 368–377.
Echeverria, D., White, R. F., & Sampaio, C. (1995). A behavioral evaluation of PCE exposure in patients and dry cleaners: A possible relationship between clinical and preclinical effects. Journal of Environmental Medicine, 37, 667–680.
Edling, C., Ekberg, K., Ahlborg, G., Alexander, R., Barregard, L., Ekenvall, L., Nilsson, L., & Svensson, B.G. (1990). Long term follow up of workers exposed to solvents. British Journal of Industrial Medicine, 47, 75–82.
Edling, C., Hellman, B., Arvidson, B., Andersson, J., Hartvig, P., Lilja, A., Valind, S., & Långström, B.(1997). Do organic solvents induce changes in the dopaminergic system? Positron emission tomography studies of occupationally exposed subjects. International Archives of Occupational and Environmental Health, 70, 180–186.
Ehele, A. L. (1986). Lead neuropathy and electrophysiological studies in low level lead exposure: A critical review. Neurotoxicology, 7, 203–216.
Ekberg, K., Barregard, L., Hagberg, S., & Sallsten, S. (1986). Chronic and acute effects of solvents on central nervous system functions in floorlayers. British Journal of Industrial Medicine, 43, 101–106.
Ellingsen, D. G., Bekken, M., Kolsaker, L., & Langård, S. (1993). Patients with suspected solvent-induced encephalopathy examined with cerebral computed tomography. Journal of Occupational Medicine, 35, 155–160.
El Massioui, F., Lesevre, N., & Fournier, L. (1986). An event-related potential assessment of attention impairment after occupational exposure to organic solvents. In C. Barber & T. Blum (Eds.), Evoked potentials III: The third international evoked potentials symposium (pp. 346–350). Stoneham,MA: Butterworths.
Elofsson, S., Gamberale, F., Hindmarsh, T., Iregrn, A., Isaksson, A., Johnsson, I., Knave, B., Lydahl, E.,Mindus, P., Persson, H. E., Philipson, B., Steby, M., Struwe, G., Soderman, E., Wennberg, A., & Widen, L. (1980). Exposure to organic solvents: A cross-sectional epidemiologic investigation on occupationally exposed car and industrial spray painters with special reference to the nervous system. Scandinavian Journal of Work Environment and Health, 6, 239–273.
Escalona, E., Yanes, L., Feo, O., & Maizlish, N. (1995). Neurobehavioral evaluation of Venezuelan workers exposed to organic solvent mixtures. American Journal of Industrial Medicine, 27, 15–27.
Eskelinen, L., Luisto, M., Tenkanen, L., & Mattei, O. (1986). Neuropsychological methods in the differentiation of organic solvent intoxication from certain neurological conditions. Journal of Clinical and Experimental Neuropsychology, 8, 239–256.
Feldman, R. G., Hayes, M. K., Younes, R., & Aldrich, F. D. (1977). Lead neuropathy in adults and children. Archives of Neurology, 34, 481–488.
Fidler, A., Baker, E., & Letz, R. (1987). Neurobehavioral effects of occupational exposure to organic solvents among construction painters. British Journal of Industrial Medicine, 44, 292–308.
Fincher, C. E., Chang, T.-S., Harrell, E. H., Kettelhut, M. C., Rea, W. J., Johnson, A., Hickey D. C., & Simon, T. R. (1997). Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults. American Journal of Industrial Medicine, 31,4–14.
Foo, S. C., Jeyaratnam, J., & Koh, D. (1990). Chronic neurobehavioral effects of toluene. British Journal of Industrial Medicine, 47, 480–484.
Freed, D., & Kandel, E. (1988). Long-term occupational exposure and the diagnosis of dementia.Neurotoxicology, 9, 391–400.
Gade, A., Mortensen, E. L., & Bruhn, P. (1988). “Chronic painter’s syndrome.” A reanalysis of psychological test data in a group of diagnosed cases, based on comparisons with matched controls. Acta Neurologica Scandinavica, 77, 293–306.
Glickman, L., Valciukas, J. A., Lilis, R., & Weisman, I. (1984). Occupational lead exposure: Effects on saccadic eye movements. International Archives of Occupational and Environmental Health, 54,115–125.
Goetz, C. G. (1985). Neurotoxins in clinical practice. New York: SP Medical and Scientific Books.
Goldblum, D., & Chouinard, G. (1985). Schizophreniform psychosis associated with chronic industrial toluene exposure: Case report. Journal of Clinical Psychiatry, 46, 350–351.
Gombault, M. (1880). Notes sûr l’état des nerfs péri-phériques dans l’empoisonnement lent par le plomb chez le cochon d’Inde. Progrés Médical (Paris), 8, 181–183.
Gorell, J. M., Johnson, C. C., Rybicki, B. A., Peterson, E. L., Kortsha, G. X., Brown, G. G., & Richardson,R. J. (1997). Occupational exposures to metals as risk factors for Parkinson’s disease. Neurology, 48,650–658.
Goyer, R. A. (1989). Mechanisms of lead and cadmium nephrotoxicity. Toxicology Letters, 46, 153–162.
Grandjean, P., Arnvig, E., & Beckmann, J. (1978). Psychological dysfunctions in lead exposed workers:Relation to biological parameters of exposure. Scandinavian Journal of Work and Environmental Health, 4, 295–303.
Graves, A., Van Duijn, C., Chandra, V., Fratiglioni, L., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K.,Mortimer, J. A., Rocca, W. A., Shalat, S. L., Soininen, H., & Hofman, A. (1991). Occupational exposures to solvents and lead as risk factors for Alzheimer’s disease: A collaborative re-analysis of case-control studies. International Journal of Epidemiology, 20, S58–S61.
Gregersen, P., Angelso, B., Nielsen, T. E., Norgaard, B., & Uldal, C. (1984). Neurotoxic effects of organic solvents in exposed workers: An occupational, neuropsychological, and neurological investigation. American Journal of Industrial Medicine, 5, 201–225.
Gregersen, P., Klausen, H., & Elsnab, C. U. (1987). Chronic toxic encephalopathy in solvent-exposed painters in Denmark 1976–1980: Clinical cases and social consequences after a 5-year follow-up.American Journal of Industrial Medicine, 11, 399–417.
Hagstadius, S., Ørbæk, P., Risberg, J., & Lindgren, M. (1989). Regional cerebral blood flow at the time of diagnosis of chronic toxic encephalopathy induced by organic-solvent exposure and after cessation of exposure. Scandinavian Journal of Work Environment and Health, 15, 130–135.
Hane, M., Axelson, O., Blume, J., Hogstedt, C., Sundell, L., & Ydreborg, B. (1977). Psychological function changes among house painters. Scandinavian Journal of Work Environment and Health, 3, 91–99.
Hänninen, H., Eskelinen, L., Husman, K., & Nurminen, M. (1976). Behavioral effects of long-term exposure to mixture of organic solvents. Scandinavian Journal of Work Environment and Health, 4,240–255.
Hänninen, H., Hernberg, S., Mantere, P., Vesanto, R., & Jalkanen, M. (1978). Psychological performance of subjects with low exposure to lead. Journal of Occupational Medicine, 20, 683–689.
Hänninen, H., Mantere, P., Hernberg, S., Seppäläinen, A. M., & Kock, B. (1979). Subjective symptoms in low-level exposure to lead. Neurotoxicology, 1, 333–347.
Hänninen, H., Antti-Poiki, M., Juntunen, J., & Koskenhvuo, M. (1991). Exposure to organic solvents and neuropsychological dysfunction: A study on monozygotic twins. British Journal of Industrial Medicine, 48, 18–25.
Hartman, D. E. (1995). Neuropsychological toxicology: Identification and assessment of human neurotoxic syndromes (2nd ed.). New York: Plenum Press.
He, F. S., Zhang, S. L., Li, G., Zhang, S. C, Huang, J. X., & Wu, Y. Q. (1988). An electrographic assessment of subclinical lead neurotoxicity. International Archives of Occupational and Environmental Health, 61, 141–146.
Hogstedt, C., Hane, M., Agrell, A., & Bodin, L. (1983). Neuropsychological test results and symptoms among workers with well-defined long-term exposure to lead. British Journal of Industrial Medicine, 40, 99–105.
Holdstein, S., Pratt, H., Golsfer, M., Rosen, G., Shenhav, R., Linn, S., Mor, A., & Barkai, A. (1986).Auditory brainstem evoked potentials in asymptomatic lead-exposed subjects. Journal of Laryngology and Otolaryngology, 100, 1031–1036.
Hooisma, J., Hänninen, H., Emmen, H., & Kulig, B. M. (1993). Behavioral effects of exposure to organic solvents in Dutch painters. Neurotoxicology and Teratology, 15, 397–406.
Iregren, A., Åkerstedt, T., Olson, B. A., & Gamberale, F. (1986). Experimental exposure to toluene in combination with ethanol intake. Scandinavian Journal of Work Environment and Health, 12,128–136.
Juntunen, J., Hernberg, S., Eistola, P., & Hupli, V. (1980). Exposure to industrial solvents and brain atrophy: A retrospective study of pneumoencephalographic findings among 37 patients with exposure to industrial solvents. European Neurology, 19, 366–375.
Kamrin, M. A. (1988). Toxicology: A primer on toxicology principles and applications. Chelsea, MI:Lewis Publishers.
Kaye, W. E., Novotny, T. E., &Tucker, M. (1987). New ceramics-related industry implicated in elevated blood lead levels in children. Archives of Environmental Health, 42, 161–164.
Kukull, W. A., Larson, E. B., Bowen, J. D., McCormic, W. C., Teri, L., Pfanschmidt, M. L., Thompson. J.D., O’Meara, E. S., Brenner, D. E., & van Belle, G. (1995). Solvent exposure as a risk factor for Alzheimer’s disease: A case-control study. American Journal of Epidemiology, 141, 1059–1071.
Lancranjan, I., Popescu, H. I., Gavenescu, O., Klepsch, I., & Serbanescu, M. (1975). Reproductive ability of workmen occupationally exposed to lead. Archives of Environmental Health, 30, 396–401.
Landrigan, P. J., Baker, E. L., Jr., Feldman, R. G., Cox, D. H., & Eden, K. V. (1976). Increased lead absorption with anemia and slowed nerve conduction in children near a lead smelter. Journal of Pediatrics, 89, 904–910.
Landtblom, A. M., Flodin, U., Soderfeldt, B., Wolfson, C., & Axelson, O. (1996). Organic solvents and multiple sclerosis: A synthesis of the current evidence. Epidemiology, 7, 429–433.
Lee, S.-H., & Lee, S. H. (1993). A study on the neurobehavioral effects of occupational exposure to organic solvents in Korean workers. Environmental Besearch, 60, 227–232.
Lilis, R. (1980). Diseases associated with exposure to chemical substances. In J. M. Last (Ed.), In public health and preventive medicine (11th ed., pp. 686–768). New York: Appleton, Century /Crofts.
Lindgren, K. N., Masten, V. L., Ford, D. P., & Bleecker, M. L. (1996). Relation of cumulative exposure to inorganic lead and neuropsychological test performance. Occupational and Environmental Medicine, 53, 472–477.
Lindström, K. (1980). Changes in psychological performance of solvent-poisoned and solvent-exposed workers. American Journal of Industrial Medicine, 1, 69–84.
Lindström, K., & Wickström, G. (1983). Psychological function changes among maintenance house painters exposed to low levels of organic solvent mixtures. Acta Psychiatrica Scandinavica,67(Suppl. 303), 81–91.
Lindström, K., Riihimäki, H., & Hänninen, K. (1984). Occupational solvent exposure and neuropsychiatric disorders. Scandinavian Journal of Work Environment and Health, 10, 321–323.
Linz, D. H., de Garmo, P. L., Morton, W. E., Wiens, A. N., Coull, B. M., & Maricle, R. A. (1986). Organic solvent-induced encephalopathy in industrial painters. Journal of Occupational Medicine, 28,119–125.
Maizlish, N. A., Langolf, G. D., Whitehead, L. W., Fine, L. J., Albers, J. W., Goldberg, J., & Smith, P. (1985).Behavioral evaluation of workers exposed to mixtures of organic solvents. British Journal of Industrial Medicine, 42, 579–590.
Mantere, P., Hänninen, H., & Hernberg, S. (1982). Subclinical neurotoxic lead effects: Two-year followup studies with psychological test methods. Neurobehavioral Toxicology and Teratology, 4,725–727.
Maroni, M., Bulgheroni, C., Cassitto, M. G., Merluzzi, F., Gilioli, R., & Foa, V. (1977). A clinical,neuropsychological and behavioral study of female workers exposed to 1,1,1-trichloroethane. Scandinavian Journal of Work Environment and Health, 3, 16–22.
McMichael, A. J., & Johnson, H. M. (1982). Long-term mortality profile of heavily exposed lead smelter workers. Journal of Occupational Medicine, 24, 375–378.
Mikkelsen, S. (1980). A cohort study of disability pension and death among painters with special regard to disabling presenile dementia as an occupational disease. Scandinavian Journal of Social Medicine, (Suppl.16), 34–43.
Mikkelsen, S., Jørgensen, M., Brown, E., & Gyldensted, C. (1988). Mixed solvent exposure and organic brain damage. Acta Neurologica Scandinavica, 78(Suppl. 118), 1–143.
Milanovic, L., Spilich, G., Vucinic, G., Knezevic, S., Ribaric, B., & Mubrin, Z. (1990). Effects of occupational exposure to organic solvents upon cognitive performance. Neurotoxicology and Teratology,12, 657–660.
Milburn, H., Mitran, E., & Crockford, G. W. (1976). An investigation of lead workers for subclinical effects of lead using three performance tests. Annals of Occupational Hygiene, 19, 239–249.
Minnema, D. J., Michelson, I. A., & Cooper, G. P. (1988). Calcium efflux and neurotransmitter release from rat hippocampal synaptosomes exposed to lead. Toxicology and Applied Pharmacology, 92,351–357.
Mitchell, J. W. (Ed.). (1987). Occupational medicine forum: Lead toxicity and reproduction. Journal of Occupational Medicine, 29, 397–399.
Moen, B. E., Riise, T., Haga, E. M., & Fossan, G. O. (1990). Reduced performance in tests of memory and visual abstraction in seamen exposed to industrial solvents. Acta Psychiatrica Scandinavica, 81,114–119.
Morgan, B. B., Jr., & Repko, J. D. (1974). Evaluation of behavioral functions in workers exposed to lead. In C. Xintaras, B. L. Johnson, & I. de Groot (Eds.), Behavioral toxicology: Early detection of occupational hazards (pp. 248–266) (HEW Publication No. (NIOSH) 74–126). Washington, DC: U.S.Government Printing Office.
Morrow L. A., Ryan, C. M., Goldstein, G., & Hodgson, M. J. (1989). A distinct pattern of personality disturbance following exposure to organic solvents. Journal of Occupational Medicine, 31, 743–746.
Morrow, L. A., Callender, T., Lottenberg, S., Buchsbaum, M. S., Hodgson, M. J., & Robin, N. (1990a). PET and neurobehavioral evidence of tetrabromoethane encephalopathy. Journal of Neuropsychiatry and Clinical Neuroscience, 2, 431– 435.
Morrow, L. A., Ryan, C. M., Hodgson, M. J., & Robin, N. (1990b). Alterations in cognitive and psychological functioning after organic solvent exposure. Journal of Occupational Medicine, 32, 444–450.
Morrow, L. A., Ryan, C. M., Hodgson, M. J., & Robin, N. (1991). Risk factors associated with persistence of neuropsychological deficits in persons with organic solvent exposure. Journal of Nervous and Mental Disease, 179, 540–545.
Morrow, L. A., Robin, N., Hodgson, M., & Kamis, H. (1992a). Assessment of attention and memory efficiency in persons with solvent neurotoxicity. Neuropsychologia, 30, 911–922.
Morrow, L. A., Steinhauer, S. R., & Hodgson, M. J. (1992b). Delay in P300 latency in patients with organic solvent exposure. Archives of Neurology, 49, 315–320.
Morrow, L. A., Kamis, H., & Hodgson, M. (1993). Psychiatric symptomatology in persons with organic solvent exposure. Journal of Consulting and Clinical Psychology, 61, 171–174.
Morrow, L. A., Steinhauer, S. R., & Condray, R. (1996). Differential associations of P300 amplitude and latency with cognitive and psychiatric function in solvent-exposed adults. Journal of Neuropsychiatry and Clinical Neuroscience, 8, 446–449.
Morrow L. A., Steinhauer, S. R., Condray, R., & Hodgson, M. (1997). Neuropsychological performance in journeymen painters under acute solvent exposure and exposure free conditions. Journal of the International Neuropsychological Society, 13, 269–275.
Morrow, L. A., Steinhauer, S. R., & Condray, R. (1998). Predictors of improvement in P300 latency in solvent exposed adults. Neuropsychiatry, Neuropsychology and Behavioral Neurology, 11, 146–150.
Muldoon, S. B., Cauley, J. A., Kuller, L. H., Morrow., L., Needleman, H. L., Scott, J., & Hooper, F. J. (1996).Effects of blood lead levels on cognitive function of older women. Neuroepidemiology, 15, 62–72.
Mutti, A., & Franchini, I. (1987). Toxicity of metabolites to dopaminergic systems and the behavioural effects of organic solvents. British Journal of Industrial Medicine, 44, 721–723.
National Institute for Occupational Safety and Health (NIOSH). (1987). Organic solvent neurotoxicity(NIOSH Publication No. 87–104) Washington, DC: US Government Printing Office.
National Research Council. (1972). Lead: Airborne lead in perspective. Washington, DC: National Academy of Sciences.
Needleman, H. L., & Bellinger, D. (1991). The health effects of low level exposure to lead. Annual Review of Public Health, 12, 111–140.
Nelson, N. A., Robbins, T. G., White, R. F., & Garrison, R. P. (1994). A case-control study of chronic neuropsychiatric disease and organic solvent exposure in automobile assembly plant workers.Occupational and Environmental Medicine, 51, 302–307.
Neshige, R., Barrett, G., & Shibaski, H. (1988). Auditory long latency event-related potentials in Alzheimer’s disease and multi-infarct dementia. Journal of Neurology,Neurosurgery and Psychiatry,51, 1120–1125.
Newton, M. P., Barrett, G., Callanan, M. M., & Towell, A. D. (1989). Cognitive event-related potentials in multiple sclerosis. Brain, 112, 1637–1660.
Ng, T. P., Ong, S. G., Lam, W. K., & Jones, G. M. (1990). Neurobehavioral effects of industrial mixed solvent exposure in Chinese printing and paint workers.Neurotoxicology and Teratology, 12,661–664.
Nielson, C. J., Nielsen, V. K., Kirkby, H., & Gyntelberg, F. (1982). Absence of peripheral neuropathy in long term lead exposed subjects. Acta Neurologica Scandinavica, 65, 241–244.
Nriagu, J. O. (1983). Occupational exposure to lead in ancient times. Science of the Total Environment,31, 105–116.
Olsen, J., & Sabroe, S. (1980). A case-reference study of neuropsychiatric disorders among workers exposed to solvents and Danish wood furniture industry.Scandinavian Journal of Social Medicine,Suppl. 16, 44–49.
Olson, B. A. (1982). Effects of organic solvents on behavioral performance of workers in the paint industry. Neurobehavioral Toxicology and Teratology, 4, 703–708.
Ørbæk, P., & Lindgren, M. (1988). Prospective clinical and psychometric investigation of patients with chronic toxic encephalopathy induced by solvents. Scandinavian Journal of Work Environment and Health, 14, 37–44.
Ørbæk, P., & Nise, G. (1989). Neurasthenic complaints and psychometric function of toluene-exposed rotogravure printers. American Journal of Industrial Medicine, 16, 67–77.
Osterberg, K., Borjesson, J., Gerhardsson, L., Schutz, A., & Skerfving, S. (1997). A neurobehavioral study of long-term occupational inorganic lead exposure. Science of the Total Environment, 201, 39–51.
Otto, D. A., Robinson, G., Baumann, S., Schroeder, S., Mushak, P., Kleinbaum. D., & Boone, L. (1985).Five-year follow-up study of children with low to moderate lead absorption: Electrophysiological evaluation. Environmental Research, 38, 168–186.
Parkinson, D. K., Ryan, C., Bromet, E. J., & Connell, M. M. (1986). A psychiatric epidemiologic study of occupational lead exposure.American Journal of Epidemiology, 123, 261–269.
Parkinson, D. K., Bromet, E. J., Cohen, S., Dunn, L. O., Dew, M. A., Ryan, C., & Schwartz, J. E. (1990).Health effects of long-term solvent exposure among women in blue-collar occupations. American Journal of Industrial Medicine, 17, 661–675.
Pasternak, G., Becker, C. E., Lash, A., Bowler, R., Estrin, W. J., & Law, D. (1989). Cross-sectionalneurotoxicology study of lead-exposed cohort. Journal of Toxicology-Clinical Toxicology, 27, 37–51.
Patterson, C, Ericson, J., Manea-Krichten, M., & Shirahata, H. (1991). Natural skeletal levels of lead in Homo sapiens uncontaminated by technological lead. Science of the Total Environment, 107,205–236.
Rabinowitz, M. B., Wetherill, G. W., & Kopple, J. D. (1976). Kinetic analysis of lead metabolism in healthy humans. Journal of Clinical Investigation, 58, 260–270.
Rasmussen, H., Olsen, J., & Lauritsen, J. (1985). Risk of encephalopathia among retired solvent-exposed workers. Journal of Occupational Medicine, 27, 561–566.
Riise, T., & Moen, B. (1990). A nested case-control study of disability pension among seamen, with special reference to neuropsychiatric disorders and exposure to solvents. Neuroepidemiology, 9,88–94.
Ryan, C. M., Morrow, L. A., Parkinson, D. K., & Bromet, E. J. (1987). Low level lead exposure and neuropsychological function in blue collar males.International Journal of Neuroscience, 36, 29–39.
Ryan, C. M., Morrow, L. A., & Hodgson, M. (1988). Cacosmia and neurobehavioral dysfunction associated with occupational exposure to mixtures of organic solvents. American Journal of Psychiatry,145, 1442–1445.
Sato, K., Endoh, K., Kaneko, T., & Johanson, G. (1991). A simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent vapours. British Journal of Industrial Medicine, 48, 342–347.
Satz, P. (1993). Brain reserve capacity on symptom onset after brain injury: A formulation and review of evidence for threshold theory. Neuropsychology, 7, 273–295.
Sborgia, G., Assennato, G., L’Abbate, N., DeMarinis, L., Paci, C., DeNicolo, M., DeMarinis, G., Montrone,N., Ferrannini, E., Specchio, L., Masi, G., & Olivieri, G. (1983). Comprehensive neurophysiological evaluation of lead-exposed workers. In R. Gilioli, M. G. Cassitto, & V. Foa (Eds.), Neurobehavioral methods in occupational health (pp. 283–294). London: Pergamon Press.
Schoenhuber, R., & Gentilini, M. (1989). Influence of occupational styrene exposure on memory and attention. Neurotoxicology and Teratology, 11, 585–586.
Schottenfeld, R. S., & Cullen, M. R. (1986). Recognition of occupation-induced posttraumatic stress disorder. Journal of Occupational Medicine, 28, 365–369.
Schwartz, B. S., Bolla, K. I., Stewart, W. S., Ford, D. D., Agnew, J., & Frumkin, H. (1993). Decrements in neurobehavioral performance associated with mixed exposure to organic and inorganic lead.American Journal of Epidemiology, 137, 1006–1021.
Seeber, A. (1989). Neurobehavioral toxicity of long-term exposure to tetrachloroethylene. Neurotoxicology and Teratology, 11, 579–583.
Selevan, S. G., Landrigan, P. J., Stern, F. B., & Jones, J. H. (1985). Mortality of lead smelter workers.American Journal of Epidemiology, 122, 673–683.
Seppäläinen, A. M., Tola, S., Hernberg, S., & Kock, B. (1975). Subclinical neuropathy at “safe” levels of lead exposure. Archives of Environmental Health, 30, 180–183.
Seppäläinen, A. M., Hernberg, S., & Kock, B. (1979). Relationship between blood lead levels and nerve conduction velocities. Neurotoxicology, 1, 313–332.
Seppäläinen, A. M., Lindström, K., & Martelin, T. (1980). Neurophysiological and psychological picture of solvent poisoning. American Journal of Industrial Medicine, 1, 31–42.
Seppäläinen, A. M., Hernberg, S., Vensanto, R., & Kock, B. (1983). Early neurotoxic effects of occupational lead exposure: A prospective study. Neurotoxicology, 4, 181–192.
Sharp, D. S., Perkins, C., Samuels, S. J., Rosenberg, J., & Rudolph, L. (1991). Lead use in California industry: Its prevalence and health implications. American Industrial Hygiene Association Journal, 52, 409–416.
Silbergeld, E. K. (1992). Neurological perspective on lead toxicity. In H. L. Needleman (Ed.), Human lead exposure (pp. 89–103). Boca Raton: CRC Press.
Simons, T. J., & Pocock, G. (1987). Lead enters bovine adrenal medullary cells through calcium channels. Journal of Neurochemistry, 48, 383–389.
Spencer, P. S., & Schaumburg, H. H. (Eds.). (1980). Experimental and clinical neurotoxicology. Baltimore: Williams & Wilkins.
Spivey, G. H., Baloh, R. W., & Brown, C. P. (1980). Subclinical effects of chronic increased lead absorption-A prospective study: III. Neurological findings at follow-up examination. Journal of Occupational Medicine, 22, 607–612.
Spurgeon, A., Gray, C. N., Sims, J., Calvert, I., Levy, L. S., Harvey, P. G., & Harrington, J. M. (1992).Neurobehavioral effects of long-term occupational exposure to organic solvents: Two comparable studies. American Journal of Industrial Medicine, 22, 325–335.
Spurgeon, A., Glass, D., Calvert, I., Cunningham-Hill, M., & Harrington, J. M. (1994). Investigation of dose related neurobehavioral effects in paintmakers exposed to low levels of solvents. Occupational and Environmental Medicine, 51, 626–630.
Steinhauer, S. R., Morrow, L. A., Condray, R., & Dougherty, G. (1997). Event-related potentials in workers with ongoing occupational exposure. Biological Psychiatry, 42, 854–858.
Stollery, B. T. (1996). Long-term cognitive sequelae of solvent intoxication. Neurotoxicology and Teratology, 18, 471–476.
Stollery, B. T., & Flindt, M. L. H. (1988). Memory sequelae of solvent intoxication. Scandinavian Journal of Work Environment and Health, 14, 45–48.
Stollery, B. T., Banks, H. A., Broadbent, D. E., & Lee, W. R. (1989). Cognitive functioning in lead workers.British Journal of Industrial Medicine, 46, 698–707.
Stollery, B. T., Broadbent, D. E., Banks, H. A., & Lee, W. R. (1991). Short term prospective study of cognitive functioning in lead workers. British Journal of Industrial Medicine, 48, 739–749.
Struwe, G., & Wennberg, A. (1983). Psychiatric and neurological symptoms in workers occupationally exposed to organic solvents-Results of a differential epidemiological study. Acta Psychiatrica Scandinavica, 67, 68–80.
Struwe, G., Mindus, P., & Jönsson, B. (1980). Psychiatric ratings in occupational health research: A study of mental symptoms in lacquerers. American Journal of Industrial Medicine, 1, 23–30.
Tang, H. W., Liang, Y. X., Hu, X. H., & Yang, H. G. (1995). Alteration in monoamine metabolites and neurobehavioral function in lead-exposed workers. Biomedical and Environmental Science, 8,23–29.
Teo, R. K. C., & Ferguson, D. A. (1985). The effects of organophosphate pesticide exposure on event-related potentials (ERPs) in pest control operators: Neurobehavioral methods in occupational and environmental health. In Extended abstracts from the Second International Symposium (pp. 163–167). Copenhagen: World Health Organization Regional Office for Europe.
Triebig, G., & Lang, C. (1993). Brain imaging technique applied to chronically solvent-exposed workers:Current results and clinical evaluation. Environmental Research, 61, 239–250.
Triebig, G., Claus, D., Csuzda, I., Druschky, K.-F., Kinzel, W., Lehrl, S., Reichwein, P., Weidenhammer,W., Weitbrecht, W.-U., Weltle, D., Schaller, K. H., & Valentin, H. (1988). Cross-sectional epidemiological study on neurotoxicity of solvents in paints and lacquers. International Archives of Occupational and Environmental Health, 60, 233–241.
Triebig, G., Barocka, A., Erbguth, F., Höll, R., Lang, C., Lehrl, S., Rechlin, T., Weidenhammer, W., & Weltle, D. (1992). International Archives of Occupational and Environmental Health, 64, 361–372.
US Environmental Protection Agency (EPA). (1986). Air quality criteria for lead (Vol. I-IV). (EPA 600/8-83//028aF). Research Triangle Park, NC: Environmental Criteria and Assessment Office,EPA.
Uzych, L. (1985). Teratogenesis and mutagenesis associated with the exposure of human males to lead:A review. Yale Journal of Biological Medicine, 58, 9–17.
Valciukas, J. A., Lilis, R., Eisinger, J., Blumberg, W. E., Fischbein, A., & Selikoff, I. J. (1978). Behavioral indicators of lead neurotoxicity: Results of a clinical field study. International Archives of Occupational and Environmental Health, 41, 217–236.
Valciukas, J. A., Lilis, R., Singer, R., Fischbein, A., Anderson, H. A., & Glickman, L. (1980). Lead exposure and behavioral changes: Comparisons of four occupational groups with different levels of lead absorption. American Journal of Industrial Medicine, 1, 421–426.
Valciukas, J. A., Lilis, R., Singer, R. M., Glickman, L., & Nicholson, W. J. (1985). Neurobehavioral changes among shipyard painters exposed to solvents. Archives of Environmental Health, 40,47–52.
van Vliet, C., Swaen, G. M. H., Volovics, A., Slangen, J. J. M., Meijers, J. M. M., de Boorder, T., & Sturmans, F. (1989). Exposure-outcome relationships between organic solvent exposure and neuropsychiatric disorders: Results from a Dutch case-control study. American Journal of Industrial Medicine, 16, 707–718.
Wasch, H. H., Estrin, W. J., Yip, P., Bowler, R., & Cone, J. E. (1989). Prolongation of the P-300 latency associated with hydrogen sulfide exposure. Archives of Neurology, 46, 902–904.
White, R. G., Robins, T. G., Proctor, S., Echeverria, D., & Rocskay, A. S. (1994). Neuropsychological effects of exposure to naphtha among automotive workers. Occupational and Environmental Medicine, 51, 102–112.
White, R. F., Proctor, S. P., Echeverria, D., Schweikert, J., & Feldman, R. G. (1995). Neurobehavioral effects of acute and chronic mixed-solvent exposure in the screen printing industry. American Journal of Industrial Medicine, 28, 221–231.
Williamson, A. M., & Teo, R. K. (1986). Neurobehavioral effects of occupational exposure to lead. British Journal of Industrial Medicine, 43, 374–380.
Williamson, A. M., & Winder, C. (1993). A prospective cohort study of the chronic effects of solvent exposure. Environmental Research, 62, 256–271.
Wittmers, L. E., Jr., Wallgren, J., Aufderheide, A. C., & Razzo, G. (1988). Lead in bone, distribution of lead in the human skeleton. Archives of Environmental Health, 43, 381–391.
Wood, R. (1981). Neurobehavioral toxicity of carbon disulfide. Neurobehavioral Toxicology and Teratology, 3, 397–405.
Zimmermann-Tansella, C., Campara, P., D’Andrea, F., Savonitto, C., & Tansella, M. (1983). Psychological and physical complaints of subjects with low exposure to lead. Human Toxicology, 2, 615–623.
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Morrow, L.A., Muldoon, S.B., Sandstrom, D.J. (2001). Neuropsychological Sequelae Associated with Occupational and Environmental Exposure to Chemicals. In: Tarter, R.E., Butters, M.A., Beers, S.R. (eds) Medical Neuropsychology. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1287-5_10
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