A Biological Comparison of Neutron Beams Used for BNCT Research

  • C. Mansfield
  • J. W. Hopewell
  • T. D. Beynon
  • R. Huiskamp


It is important for the BNCT community to be able to compare and predict the biological effects of mixed radiation fields at various centres. A quantitative comparison of the beams would allow more valid discussions of radiobiological and clinical data between centres. If a biological system could be irradiated in various BNCT facilities and its radiation response analysed such a comparison will be possible. If the beams at each centre can thus be compared the preclinical and radiobiological studies performed at other centres will not have to be repeated at new centres, such as at Birmingham, and comparison of clinical data will be more meaningful.

This report describes the design of an in vitro experiment which fulfils these criteria. Cell survival will be determined in relation to the depth in a phantom following irradiation in a BNCT beam. To overcome the problems of the variable repair of sub- lethal damage from the gamma radiation component of any beam during the irradiation period all irradiations will be performed at 4°C The different components of the total dose rate at each position in the phantom will be estimated using paired ionisation chambers and activation foils. To ensure that a valid comparison is being made, the beam survival curves will be compared to x-ray survival curves produced at each centre in this study.


Boron Neutron Capture Therapy Relative Biological Effectiveness Epithermal Neutron Dose Component High Flux Reactor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J.A. Coderre, M.S. Makar, P.L. Micca, M.M. Nawrocky, H.B. Liu, D.D. Joel, D.N. Slatkin, and H.I. Amols, Derivations of relative biological effectiveness for the high LET radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo, Int J of Radiat Oncol, Biol, Phys, 27(5): 1121–1129, 1993.CrossRefGoogle Scholar
  2. 2.
    R. Huiskamp, A.C. Begg, V.G.A. Gregoire, R. Verrijk, D. Gabel, A. Siefert, and R.L. Moss, Radiobiology studies at Petten: Status on cell culture, mice and dog experiments, in Progress in Neutron Capture Therapy for Cancer, ed. B.J. Allen et al., Plenum Press, New York, 1992, pp. 485–488.CrossRefGoogle Scholar
  3. 3.
    PR. Gavin, S.L. Kraft, R. Huiskamp, and J.A. Coderre, A review: CNS effects and normal tissue tolerance in dogs, J of Neuro Oncol, 33(1–2):59–70, 1997.Google Scholar
  4. 4.
    J. Benczzik, T. Seppälä, J. Hopewell, M. Snellman, I. Auterinen, R. Joensuu, U. Abo Ramadan, S. Savolainen, M. Färkkilä, H. Joensuu, M. Kallio, M. Kulvik, and M. Tenhunun, Large animal model for healthy tissue tolerance study in BNCT, in “Frontiers in Neutron Capture Therapy,” M.F. Hawthorne, K. Shelly, R.W. Wiersema, eds., Kluwer Academic/Plenum Publishers, New York, 2001, pp. 1233–1238.CrossRefGoogle Scholar
  5. 5.
    C.P.J. Raaijmakers, and M.W. Konijnenberg, Determination of dose components in phantoms irradiated with an epithermal neutron beam for boron neutron capture therapy, Med Phys, 22(3):321–329, 1995.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • C. Mansfield
    • 1
  • J. W. Hopewell
    • 2
  • T. D. Beynon
    • 1
  • R. Huiskamp
    • 3
  1. 1.School of Physics and AstronomyUniversity of BirminghamBirminghamUK
  2. 2.Research InstituteOxford UniversityOxfordUK
  3. 3.Netherlands Energy Research FoundationECNPettenThe Netherlands

Personalised recommendations