Abstract
Glioblastoma multiforme (GBM) accounts for about 80% of all adult malignant gliomas. Despite aggressive surgery, chemotherapy and radiation therapy, GBM continues to be one of the most intractable brain tumors. The median and 5-year survivals are typically 9 to 10 months and <5%, respectively.1 For primary malignant brain tumors, the most powerful prognostic factors are histology, age and functional status.2 Although GBM rarely metastasizes to other sites and organs, the tumor cells infiltrate deeply into the surrounding brain and may even reach the contralateral hemisphere. External beam photon radiation therapy cannot ablate the infiltrating GBM cells because radiation doses high enough to kill those cells would cause unacceptable necrosis of normal brain tissues. Boron neutron capture therapy (BNCT) has the potential to address this inadequacy through a more selective Irradiation of GBM cells.
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Diaz, A.Z. et al. (2001). Boron Neutron Capture Therapy for Glioblastoma Multiforme. In: Hawthorne, M.F., Shelly, K., Wiersema, R.J. (eds) Frontiers in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1285-1_5
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DOI: https://doi.org/10.1007/978-1-4615-1285-1_5
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