Quantitative MRI in Assessing Irradiation Effect in Dog Brain

  • U. Abo Ramadan
  • J. Benczik
  • H. Joensuu
  • R. Joensuu
  • M. Kallio
  • L. Kankaanranta
  • S. Savolainen
  • M. Snellman
  • J. Tanttu
  • M. Tenhunen

Abstract

The effect of radiation to the central nervous system has been studied frequently.1, 2, 3, 4, 5 Early delayed injury occurs a few weeks to 3 months after therapy. Late radiation injury, which is observed a few months to 10 or more years after radiotherapy, is often irreversible, progressive, and is seen as focal injury or diffuse white matter injury. The degree of lesion and its characteristics depend upon the radiation dose, the time within which this dose is delivered, and the type of the target cell. The radiation response of normal brain has been investigated in a variety of animal models. Available data suggest that non-human primates and dogs are the best models of the human brain, with similar dose requirements to induce damage, and similar radiographic and histopathologic changes.6

Keywords

Boron Macromolecule Clinac 

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • U. Abo Ramadan
    • 1
    • 2
  • J. Benczik
    • 1
    • 3
  • H. Joensuu
    • 2
  • R. Joensuu
    • 2
  • M. Kallio
    • 2
  • L. Kankaanranta
    • 2
  • S. Savolainen
    • 1
    • 2
  • M. Snellman
    • 1
  • J. Tanttu
    • 4
  • M. Tenhunen
    • 2
  1. 1.University of HelsinkiFinland
  2. 2.Helsinki University Central HospitalFinland
  3. 3.Research Institute of Helsinki University Central HospitalFinland
  4. 4.Picker Nordstar, Inc.Finland

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