Analysis of in Vivo Uptake for Boron Neutron Capture Synovectomy

  • E. Binello
  • S. Shortkroff
  • R. E. Shefer
  • A. G. Jones
  • A. Davison
  • T. Thornhill
  • J. C. Yanch

Abstract

Boron Neutron Capture Synovectomy (BNCS) has been proposed as a new application of the boron neutron capture reaction for the treatment of Rheumatoid Arthritis.1 Rheumatoid Arthritis (RA) is an autoimmune disease of unknown origin, primarily characterized by an inflammation of the synovium, the membrane lining the joint space. Prolonged synovial inflammation results in the secretion of various enzymes which degrade cartilage and bone, eventually leading to the loss of joint function.

Keywords

Arthritis Europe Boron Washout Synovitis 

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • E. Binello
    • 1
  • S. Shortkroff
    • 2
  • R. E. Shefer
    • 3
  • A. G. Jones
    • 4
  • A. Davison
    • 5
  • T. Thornhill
    • 2
  • J. C. Yanch
    • 1
  1. 1.Department of Nuclear Engineering and Whitaker College of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of Orthopedic SurgeryBrigham & Women’s HospitalBostonUSA
  3. 3.Newton Scientific IncorporatedCambridgeUSA
  4. 4.Department of RadiologyHarvard Medical SchoolBostonUSA
  5. 5.Department of ChemistryMassachusetts Institute of TechnologyCambridgeUSA

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