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In Vitro Uptake Study of 5-Carboranyl Uridine and Its Derivatives

  • Toshinari Hasegawa
  • Munekazu Nakaichi
  • Sanenori Nakama
  • Hiroyuki Nakamura
  • Yoshinori Yamamoto
  • Masao Takagaki
  • Akira Takeuchi

Abstract

Recently, much attention has been focused on synthesis of new tumor-seeking boron compounds to improve the therapeutic efficacy of BNCT, and boronated uridine is one being expected for favorable uptake by tumor cells by the pathways for the synthesis of DNA. Previous studies on boronated uridines1 have shown that such compounds have high cytotoxicity in cultured cells, limiting their potential clinical use. In this experiment, 5-carboranyl uridine and its derivatives, characterized by high water solubility and low cytotoxicity, were investigated for their accumulation in cultured glial tumor cells. In vivo biodistributions of these boronated uridines in brain tumor-bearing rats were also investigated.

Keywords

Boron Concentration Boron Compound Cell Killing Effect Reactor Institute Inductivity Couple Plasma Atomic Emission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    L. Liu, R.F. Barth, W. Tjarks, A.H. Soloway, and A.K.M. Amisuzzaman. In vitro and in vivo evaluation of carboranyl uridines as boron delivery agents for neutron capture therapy. Anticancer Res., 16:113–120, 1996.PubMedGoogle Scholar
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    S.R. Tamat, D.E. Moore, and B.J. Allen. Determination of boron in biological tissues by inductivity coupled plasma atomic emission spectrometry. Anal. Chem., 59:2161–2164, 1987.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Toshinari Hasegawa
    • 1
  • Munekazu Nakaichi
    • 1
  • Sanenori Nakama
    • 1
  • Hiroyuki Nakamura
    • 2
  • Yoshinori Yamamoto
    • 2
  • Masao Takagaki
    • 3
  • Akira Takeuchi
    • 4
  1. 1.Department of Veterinary SurgeryYamaguchi UniversityYamaguchiJapan
  2. 2.Department of ChemistryTohoku UniversitySendaiJapan
  3. 3.Research Reactor InstituteKyoto UniversityOsakaJapan
  4. 4.College of Bioresource SciencesNihon UniversityKanagawaJapan

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