In Vitro Uptake Study of 5-Carboranyl Uridine and Its Derivatives
Recently, much attention has been focused on synthesis of new tumor-seeking boron compounds to improve the therapeutic efficacy of BNCT, and boronated uridine is one being expected for favorable uptake by tumor cells by the pathways for the synthesis of DNA. Previous studies on boronated uridines1 have shown that such compounds have high cytotoxicity in cultured cells, limiting their potential clinical use. In this experiment, 5-carboranyl uridine and its derivatives, characterized by high water solubility and low cytotoxicity, were investigated for their accumulation in cultured glial tumor cells. In vivo biodistributions of these boronated uridines in brain tumor-bearing rats were also investigated.
KeywordsBoron Concentration Boron Compound Cell Killing Effect Reactor Institute Inductivity Couple Plasma Atomic Emission
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- 2.Y. Yamamoto. Search for new tumor-seeking boron compounds in Japan, In “Advances in Neutron Capture Therapy. Volume II, Chemistry and Biology,” B. Larsson, J. Crawford, and R. Weinreich, eds., Elsevier, Amsterdam, 1997, pp. 22–29.Google Scholar