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Boron Neutron Capture-Enhanced Fast Neutron Therapy (BNC/FNT) for Non-Small Cell Lung Cancer in Canine Patients

  • K. J. Stelzer
  • P. R. Gavin
  • R. Risler
  • H. Kippenes
  • M. F. Hawthorne
  • D. W. Nigg
  • G. E. Laramore

Abstract

The clinical utility of boron neutron capture (BNC) with thermal/epithermal neutron beams has been limited to tumors located at shallow depths, such as in the brain and skin. Capture of the thermal neutron component within a predominantly fast neutron (FN) beam could selectively enhance cytotoxicity in deeply located tumors, such as lung cancer, thereby increasing the availability of this treatment to far greater numbers of cancer patients.1, 2, 3, 4 Even combining concurrent chemotherapy and photon radiation followed by surgery for treatment of locally advanced non-small cell lung cancer (NSCLC), local recurrence was detected in 40% of treatment failures.5 With improved effectiveness of systemic therapies, local control of bulky disease at the primary site becomes increasingly important for improving median survival and increasing probability of cure. The purpose of this ongoing study was to determine the feasibility and toxicity of BNC/FNT in a trial for dogs with spontaneous NSCLC.

Keywords

Spinal Cord Injury Fast Neutron Neutron Beam Boron Neutron Capture Therapy Radiation Pneumonitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • K. J. Stelzer
    • 1
  • P. R. Gavin
    • 2
  • R. Risler
    • 1
  • H. Kippenes
    • 2
  • M. F. Hawthorne
    • 3
  • D. W. Nigg
    • 4
  • G. E. Laramore
    • 1
  1. 1.Department of Radiation OncologyUniversity of Washington Medical CenterSeattleUSA
  2. 2.Department of Veterinary Clinical SciencesWashington State UniversityPullmanUSA
  3. 3.Department of Chemistry and BiochemistryUniversity of CaliforniaLos AngelesUSA
  4. 4.Idaho National Engineering and Environmental LaboratoryIdaho FallsUSA

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