Soybeans and Cancer Prevention: A Complex Food and a Complex Disease

  • Diane F. Birt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 492)


There is a human tendency to simplify complex and chaotic relationships so that we can better communicate information. This is certainly true with public health information. In considering soybeans and cancer prevention, this has resulted in attempts to translate the associations between dietary intake and disease as being due to single compounds, and the influences of complex biological processes as being through single or simple mechanisms. We anticipate that the series of three papers on the impact of soybeans on cancer will demonstrate the complexity of the soybean and the complexity of the impact of soybeans and constituents from soybeans on carcinogenesis. The first of these three papers will provide a foundation for considering the complexity of soybeans and the complexity of the cancer process in attempting to understand and to optimize strategies for the use of dietary soybeans or soybean constituents in the prevention of human cancer.


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  1. 1.
    Wilson, L.A., Murphy, P.A., and Gallagher, P. Japanese Soyfoods: Markets and Processes I, 1–63. 1991. Iowa State University, Ames, IA, CCUR. Ref Type: ReportGoogle Scholar
  2. 2.
    Hammond, E.G., Johnson, L.A., and Murphy, P.A. (1993) Properties and Analysis. In Caballero, B., Trugo, L.C., and Finglas, P. (eds.)Enclyclopedia of Food Science Food Technology and Nutrition. Academic Press, New York City, pp 4223–5.3Google Scholar
  3. 3.
    Liener, I.E. (1995) Possible adverse effects of soybean anticarcinogens.American Institute of Nutrition7445–750S.Google Scholar
  4. 4.
    Wang, H.J. and Murphy, P.A. (1996) Mass balance of isoflavones study in soybean processing.J. Agric. Food Chem.44, 2377–2383.CrossRefGoogle Scholar
  5. 5.
    Song, T., Barua, K., Buseman, G., and Murphy, P.A. (1998) Soy isoflavone analysis: quality control and new internal standard.Am. J. Clin. Nutr68 (Suppl), 1474S–1479S.PubMedGoogle Scholar
  6. 6.
    Wang, H.J. and Murphy, P.A. (1994) Isoflavones of commercial soybean foods. J.Agric. Food Chem.42, 1666–1673.CrossRefGoogle Scholar
  7. 7.
    Hirayama, T. (1979) Epidemiology of prostate cancer with special reference to the role of diet. Natl. Cancer Inst. Monogr. 53, 149–155.PubMedGoogle Scholar
  8. 8.
    Nomura, A., Henderson, B.E., and Lee, J. (1978) Breast cancer and diet among the Japanese in Hawaii. Am. J. Clin. Nutr., 31, 2020–2025.PubMedGoogle Scholar
  9. 9.
    Messina, M.J., Persky, V., Setchell, K.D.R., and Barnes, S. (1994) Soy intake and cancer risk: A review of the in vitro and in vivo data. Nutr. Cancer, 21, 113–131.PubMedCrossRefGoogle Scholar
  10. 10.
    Fournier, D.B., Erdman, J.W., Jr., and Gordon, G.B. (1998) Soy, its components, and cancer prevention: A review of the in vitro animal, and human data. Cancer Epidemiol. Biomarkers Prev. 7, 1055–1065.PubMedGoogle Scholar
  11. 11.
    Kennedy, A.R. (1998) Chemopreventive agents: Protease Inhibitors. Pharmacology and Therapeutics 78, 167–209.PubMedCrossRefGoogle Scholar
  12. 12.
    Sorensen, I.K., Kristiansen, E., Mortensen, A., Nicolaisen, G.M., Wijnandes, J.A.H., Van Kranen, H.J., and Van Kreijl, C.F. (1998) The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin; mouse. Cancer Letters 130, 217–225.PubMedCrossRefGoogle Scholar
  13. 13.
    St.Clair, W.H., Billings, P.C., and Kennedy, A.R. (1990) The effects of the Bowman-Birk protease inhibitor on c-myc expression and cell proliferation in the unirradiated and irradiated mouse colon. Cancer Letters 52, 145–152.CrossRefGoogle Scholar
  14. 14.
    Koratkar, R. and Rao, A.R. (1997) Effect of Soya Bean Saponins on AzoxymethaneInduced Preneoplastic Lesions in the Colon of Mice. Nutr. Cancer 27, 206–209.PubMedCrossRefGoogle Scholar
  15. 15.
    Thompson, L.U. (1993) Potentional health benefits and problems associated with antinutrients in foods. Food Res. Intl. 26, 131–149.CrossRefGoogle Scholar
  16. 16.
    Yang, G.Y. and Shamsuddin, A.M. (1995) IP6-induced growth inhibition and differentiation of HT- 29 human colon cancer cells: Involvement of intracellular inositol phosphates. Anticancer Res. 15, 2479–2487.PubMedGoogle Scholar
  17. 17.
    Ullah, A. and Shamsuddin, A.M. (1990) Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 11, 2219–2222.PubMedCrossRefGoogle Scholar
  18. 18.
    Shamsuddin, A.M. (1995) Inositol phosphates have novel anticancer function. J. Nutr. 125, 7255–7325.Google Scholar
  19. 19.
    Clarke, R., Hilakivi-Clarke, L., Cho,E., James, M.R., and Leonessa, F. (1996) Estrogens, phytoestrogens, and breast cancer.Adv. Exp. Med. Biol.401, 63–85.PubMedCrossRefGoogle Scholar
  20. 20.
    Hsieh, C.Y., Santell, R.C., Haslam, S.Z., and Helferich, W.G. (1998) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cellsin vitroandin vivo. Cancer Res., 58, 3833–3838.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Diane F. Birt
    • 1
  1. 1.Department of Food Science and Human Nutrition and Center for Designing Foods to Improve Nutrition 2312 Food Sciences BuildingIowa State UniversityAmes

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