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Neurotoxic Factors in Parkinson’s Disease and Related Disorders pp 69–76Cite as

Isoquinoline Neurotoxins

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Abstract

Various l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-like isoquinolines (IQs) were found in the brain or cerebrospinal fluid in Parkinson’s disease (PD). Among these IQs, tetrahydroisoquinoline (TIQ), 1-benzyl-TIQ, 2[N]-methyl-5,6-dihydroxy-TIQ (N-methyl-norsalsolinol) and R-l,2[N]-dimethyl-5,6-dihydroxy-TIQ [(R)-N-methyl-salsolinol] have been extensively studied. The properties of IQs as neurotoxins are similar to those of MPTP. Further studies are needed to elucidate the relationship between IQ neurotoxins and PD.

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Authors and Affiliations

  1. Institute for Comprehensive Medical Science, Fujita Health University Toyoake, Aichi, 470-1192, Japan

    Toshiharu Nagatsu

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  1. Toshiharu Nagatsu
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  1. University of Ulm Medical School, Ulm, Germany

    Alexander Storch

  2. Loyola University Stritch School of Medicine, Maywood, Illinois, USA

    Michael A. Collins

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Nagatsu, T. (2000). Isoquinoline Neurotoxins. In: Storch, A., Collins, M.A. (eds) Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1269-1_7

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  • DOI: https://doi.org/10.1007/978-1-4615-1269-1_7

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-1269-1

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