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Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro-ß-Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson’s Disease Patients

  • S. Kretschmer
  • T. Class
  • H.-U. Wolf

Abstract

Recent investigations indicate a correlation between the pathogenesis of Parkinson’s disease (PD) and the occurrence of some N-heterocyclic compounds, especially derivatives of 1,2,3,4-tetrahydroisoquinoline (THIQ) and l,2,3,4-tetrahydro-ß-carboline (THBC). Whereas the occurrence of some derivatives of THIQ could be demonstrated in human blood and urine, the presence of specific THBC’s remained unclear because of the lack of a sensitive and selective analytical screening method, generally suitable for a larger series of THBC’s. In order to be able to determine THBC’s of a larger variety of structures in urine samples of PD patients and control persons, we developed an analytical method based on gas chromatography (GC) with mass spectrometric (MS) detection.

Keywords

Urine Sample Human Blood Disease Patient Carbonyl Compound Reference Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • S. Kretschmer
    • 1
  • T. Class
    • 1
  • H.-U. Wolf
    • 1
  1. 1.Department of Pharmacology and Toxicology PTRL EuropeUniversity of UlmUlmGermany

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