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Contribution of Intracellular Non-Haem Iron, NF-kB Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection

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Neurotoxic Factors in Parkinson’s Disease and Related Disorders

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Abstract

Parkinson’s Disease (PD) involves the progressive degeneration of dopamine neuron cell bodies arising in the substantia nigra and extending through its terminals into the striatum. The disease is best described as a deficiency of striatal dopamine. The mechanism of neurodegeneration is an enigma in spite of the many hypothesis and efforts made so far to identify it (Youdim and Riederer, 1997; Jenner, 1998). Nevertheless, in the past few years much has been learnt about the chemical pathology of PD, especially in the substantia nigra pars compacta (SNpc). The most valid current hypothesis concerning the pathogenesis of PD is an on going oxidative stress (OS) which expresses itself with biochemical changes selectively in SNpc (Riederer et al., 1989; Youdim et al., 1993a,b; Gerlach et al., 1994; Gotz et al., 1994; Jenner and Olanow, 1996; Olanow and Youdim, 1996; Youdim and Riederer, 1997; Jenner, 1998).

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Authors and Affiliations

  1. Technion-Faculty of Medicine, Eve Topf and National US Parkinson Foundation Centers for Neurodegenerative Diseases, Haifa, 31096, Israel

    Edna Grünblatt, Silvia Mandel, Yona Royak & Moussa B. H. Youdim

  2. Fogarty International Center for Advance Studies in Human Health, NIH, NIMH, Laboratory of Neurodegeneration and Neuroprotection, Bethesda, USA

    Moussa B. H. Youdim

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  1. Edna Grünblatt
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  1. University of Ulm Medical School, Ulm, Germany

    Alexander Storch

  2. Loyola University Stritch School of Medicine, Maywood, Illinois, USA

    Michael A. Collins

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Grünblatt, E., Mandel, S., Royak, Y., Youdim, M.B.H. (2000). Contribution of Intracellular Non-Haem Iron, NF-kB Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection. In: Storch, A., Collins, M.A. (eds) Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1269-1_26

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