Abstract
Catecholamine derived aldehydes are the products of monoamine oxidase (MAO) action on catecholamines (CA). There are three major CA in human tissues: norepinephrine (NE), epinephrine (Epi), and dopamine (DA). All three are central neurotransmitters and, in addition, NE and Epi are hormones secreted by the adrenal medulla. MAO has two isoforms: A and B. NE and Epi are the preferred substrates for MAO A (Rivett et al., 1982). DA is metabolized by both MAO A and B (Rivett et al., 1982). The MAO A product of either NE or Epi is 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL). The MAO product of DA is 3,4-dihydroxyphenylacetaldehyde (DOP-AL). Researchers initially considered these aldehydes, synthesized on the outer mitochondrial membrane, merely ephemeral intermediates in CA metabolism. However, the synthesis of sufficient quantities of chemically pure CA aldehydes has led to an understanding of their role in mitochondrially mediated apoptotic neuron death.
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Burke, W.J. et al. (2000). Catecholamine-Derived Aldehyde Neurotoxins. In: Storch, A., Collins, M.A. (eds) Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1269-1_18
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