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T-Independent IgA Responses to Microbial Polysaccharides

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 491)

Abstract

There is accumulating evidence indicating the presence in vivo of T -independent routes of IgA response in addition to the conventional T-dependent IgA response. Factors influencing these alternative pathways of IgA responses may include the structural characteristics of a stimulating antigen, the nature of responding B cells, and the microenvironment. The structural complexity of polysaccharide antigens has made it difficult to summarize a general scheme for the antibody responses they induce. Instead, one may expect that each individual polysaccharide may be able to create a unique microenvironment by activation of specific cell populations in the repertoires of non-T cell types. A specific pattern of B cell response may thus be elicited by TI stimulation. Recognition of such a unique property of a TI antigens is necessary for us to better understand the T -independent IgA response. Information obtained may have an impact on the development of vaccination strategies directed at the mucosal immunity mediated by IgA antibodies.

Keywords

Celiac Disease Antibody Response Germinal Center Class Switching Follicular Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  1. 1.Immunology Laboratory, Columbia Genome CenterCollege of Physicians & SurgeonsColumbia UniversityNew YorkUSA

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