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Neurotransplants in Treatment of Parkinson’s Disease

  • Chapter
Basal Ganglia and Thalamus in Health and Movement Disorders

Abstract

Parkinson’s disease is a neurodegenerative disorder eharaeterized mainly by a loss of dopaminergic neurons in the substantia nigra that results in deafferentation of the striatum. In patients, this is manifested in tremor, rigidity, hypokinesia, and postural instability (Agid, 1991; Wiehmann and DeLong, 1993; Pogarell and Oertel, 1999). Initial symptoms of Parkinson’s disease emerge after a 60–80% loss of the nigral dopaminergic neurons and reduction of striatal dopamine (Berheimer et al., 1973; Kish et al., 1988). The conventional dopamine replacement therapy using L-dopa or dopamine agonists initially provides substantial improvement but finally leads to complications, such as disabling dyskinesias, motor fluctuations, and L-dopa non-responsive features (freezing, postural instability, dementia, and autonomic dysfunction) (King, 1999; Merman and Mouradian, 1999). Such complications prompted the search for alternative treatments to restore impaired functions in patients with Parkinson’s disease.

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  1. Institute of Developmental Biology, RAS, Institute of Normal Physiology, RAMS, Moscow, 117808, Russia

    Michael V. Ugrumov

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  1. The University of Iowa, Iowa City, Iowa, USA

    Kristy Kultas-Ilinsky  & Igor A. Ilinsky  & 

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Ugrumov, M.V. (2001). Neurotransplants in Treatment of Parkinson’s Disease. In: Kultas-Ilinsky, K., Ilinsky, I.A. (eds) Basal Ganglia and Thalamus in Health and Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1235-6_32

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