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Physiology of Subthalamic Nucleus Neurons in Animal Models of Parkinson’s Disease

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Basal Ganglia and Thalamus in Health and Movement Disorders

Abstract

The subthalamic nucleus (STN) has been reported to play an important role in the control of movement. It is described as a “driving force of the basal ganglia” because it exerts a glutamatergic excitatory influence on the output structures of the system: the pars reticulata of substantia nigra (SNr) and the internal part of globus pallidus (GPi, the equivalent of the entopeduncular nucleus (EP) in rodents) (Kitai and Kita, 1987; Robledo and Feger, 1990). From the review of Parent and Hazrati (1995), it appears that the STN, like the striatum, is a major structure through which cortical signals are transmitted to the output nuclei of the basal ganglia. Moreover, in addition to the direct cortico-STN pathway, the cortex influences the STN through an indirect pathway involving the striatum and the external part of globus pallidus (GPe, an equivalent of GP in rodents).

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Authors and Affiliations

  1. Laboratoire de Neurosciences Précliniques, Inserm U.318, Université Joseph Fourier, CHRU-Pavillon B, BP217, 38043, Grenoble Cedex 09, France

    Abdelhamid Benazzouz, Zhongge Ni, Rabia Bouali-Benazzouz, Sorin Breit, Adnan Kousie, Valerie Fraix, Elena Moro & Alim-Louis Benabid

  2. Department of Physiology, Jinzhou Medical College, Jinzhou, P.R. China

    Dongming Gao

  3. Department of Neurosciences, University of Grenoble, France

    Paul Krack

  4. Neurology Department, University of Kiel, 24105, Kiel, Germany

    Paul Krack

  5. Department of Physiology, Université Joseph Fourier, CHRU-Pavillon B, BP217, 38043, Grenoble Cedex 09, France

    Pierre Pollak

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    Kristy Kultas-Ilinsky  & Igor A. Ilinsky  & 

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Benazzouz, A. et al. (2001). Physiology of Subthalamic Nucleus Neurons in Animal Models of Parkinson’s Disease. In: Kultas-Ilinsky, K., Ilinsky, I.A. (eds) Basal Ganglia and Thalamus in Health and Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1235-6_21

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