Abstract
The goal of the present review is to determine the contribution of the globus pallidus to movement disorders. We will examine changes in the activity and reactivity of individual globus pallidus neurons in the monkey, as the normal animal is rendered hypokinetic and parkinsonian, following intoxication with the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine), and then hyperkinetic and dyskinetic, by pharmacological treatment with dopamine agonists. We will also examine data obtained in normal monkeys rendered transiently dyskinetic by intra-pallidal injection of an antagonist of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). We interpret the changes in the light of recent data from the literature.
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Filion, M. (2001). Physiology of Globus Pallidus Neurons in Movement Disorders. In: Kultas-Ilinsky, K., Ilinsky, I.A. (eds) Basal Ganglia and Thalamus in Health and Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1235-6_20
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DOI: https://doi.org/10.1007/978-1-4615-1235-6_20
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