The Permeability of MIPS to Gases

  • Gordon J. Cooper
  • Ram Dixit
  • June Nasrallah
  • Walter F. Boron


The pioneering work of Overton at the turn of the last Century provided insight into how small neutral solutes enter cells, showing that the membrane permeability of a solute is proportional to solute’s oil/water partition coefficient. This principle has been extended to gases, and it is commonly believed that gases diffuse freely through the lipid phase of cell membranes. However, in the last several years, a number of observations have challenged this dogma, and is becoming clear that not only can membranes have an extremely low gas permeability, but channels in some cases appear to augment gas permeability


Lysis Time Acidification Rate Peribacteroid Membrane Intracellular Carbonic Anhydrase Sustained Acidification 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Gordon J. Cooper
    • 1
  • Ram Dixit
    • 2
  • June Nasrallah
    • 2
  • Walter F. Boron
    • 3
  1. 1.School of Biological SciencesUniversity of ManchesterManchesterUK
  2. 2.Dept of Plant BiologyCornell UniversityIthacaUSA
  3. 3.Dept of Cellular and Molecular PhysiologyYale UniversityNew HavenUSA

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