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Urinary Excretion of Aquaporin-2 Water Channel is Dominant in Pathological State of Arginine Vasopressin-Induced Impaired Water Excretion

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Abstract

There is impaired water excretion in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH), congestive heart failure, liver cirrhosis with ascites and adrenal insufficiency (Bartter and Schwartz 1967, Bichet et al., 1982, Schrier 1988a, b). In these clinical settings there is hyponatremia to a various extent. Non-suppressible release of arginine vasopressin (AVP) is found despite hypoosmolality, which should suppress plasma AVP to undetectable levels (Bartter and Schwartz 1967, Bichet et al., 1982, Schrier 1988a, b, Ishikawa et al., 1982, Ishikawa 1986).

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© 2000 Springer Science+Business Media New York

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Ishikawa, S. et al. (2000). Urinary Excretion of Aquaporin-2 Water Channel is Dominant in Pathological State of Arginine Vasopressin-Induced Impaired Water Excretion. In: Hohmann, S., Nielsen, S. (eds) Molecular Biology and Physiology of Water and Solute Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1203-5_29

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  • DOI: https://doi.org/10.1007/978-1-4615-1203-5_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5439-0

  • Online ISBN: 978-1-4615-1203-5

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