Expression and Regulation of Aquaporin-1 and Endothelial Nitric Oxide Synthase in Relationship with Water Permeability Across the Peritoneum

  • Olivier Devuyst
  • Sophie Combet
  • Jean-Luc Balligand
  • Eric Goffin
  • Jean-Marc Verbavatz


Over the past 25 years, peritoneal dialysis (PD) has become an established treatment for end-stage renal disease (ESRD), accounting for about 15% of the total number of patients on dialysis worldwide (Gokal and Mallick 1999). To perform PD, a catheter is inserted into the peritoneal cavity and a solution (dialysate) is infused through it. The dialysate remains in the peritoneal cavity for some hours (dwell time), and is then drained out before fresh dialysate is reinfused (the drainage-reinfusion procedure is called an exchange). Four exchanges are performed daily in continuous ambulatory peritoneal dialysis (CAPD); a mechanical device can also be used to infuse and drain the dialysate during the night, in combination with one or two day-time exchanges (automated peritoneal dialysis, APD) (Gokal and Mallick 1999).


Nitric Oxide Peritoneal Dialysis Water Permeability Continuous Ambulatory Peritoneal Dialysis Peritoneal Dialysis Patient 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Olivier Devuyst
    • 1
  • Sophie Combet
    • 2
  • Jean-Luc Balligand
    • 3
  • Eric Goffin
    • 1
  • Jean-Marc Verbavatz
    • 2
  1. 1.Div. of NephrologyUniversité catholique de Louvain Medical SchoolBrusselsBelgium
  2. 2.Dept of Cell BiologyCEA SaclayGif-sur-YvetteFrance
  3. 3.Div. of Pharmacology and TherapeuticsUniversité catholique de Louvain Medical SchoolBrusselsBelgium

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