The Possible Role of Intestinal Surfactantlike Particles in the Absorption of Triacylglycerols in the Rat
The process of triacylglycerol absorption has passed through at least three quantum leaps of progress. In the 1950s and 1960s there was a tremendous increase in knowledge concerning the intralumenal and intracellular fate of ingested triacylglycerols. By the end of this explosion of information the current concepts were defined: intralumenal hydrolysis, incorporation of fatty acids and monoglycerides into mixed bile salt micelles, uptake of lipid (not by pinocytosis) into the enterocyte with reformation of triacylglycerols, and finally, intracellular packaging and secretion into lymph via lipoproteins (Senior, 1964; Hofmann and Small, 1967; Johnston, 1968; Borgström, 1974; Friedman and Nylund, 1980). In addition, the intracellular pathways of fat absorption were described using transmission electron microscopy (Palay and Karlin, 1959; Strauss, 1966; Rubin, 1966; Sjostrand and Borgstrom, 1967). Although the details and mechanisms of the lumenal events were largely understood at that time, the precise intracellular events and their compartmentalization were unclear.
KeywordsSurfactant Corn Cytosol Triacylglycerol Colchicine
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