Classical histoplasmosis is an intracellular mycosis of the reticuloendothelial system involving lymphatic tissue, lungs, liver and spleen, but also brain, kidneys and other organs. Disease occurs in both tropical and temperate zones, particularly the USA. Cases have been reported from 30 countries. It is caused by Histoplasma capsulatum a dimorphic fungus found in the soil. Contamination occurs by inhaling spores. Some highly prevalent areas of histoplasmosis show positive histoplasmin indexes in over 30% of the evaluated individuals (96). Developed countries have been registering an increasing number of cases, as a result of immigration and travelling to endemic areas (48).
KeywordsLymphoma Tuberculosis Radionuclide Meningitis Encapsulation
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