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The Glutathione System in Alkylator Resistance

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Clinically Relevant Resistance in Cancer Chemotherapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 112))

Abstract

One of the greatest obstacles in the effective chemotherapy of neoplastic disease is the presence of tumor chemoresistance. In some instances, a tumor can be intrinsically resistant to chemotherapy or, in other cases, develop resistance during the course of antineoplastic treatment. This acquired resistance is thought to occur through the selection of a subpopulation of resistant tumor cells as the tumor is exposed to chemotherapy. To complicate chemotherapeutic drug selection, it has been found that once a tumor demonstrates resistance to one class of drugs, it will often be resistant to other classes that share structural or functional homology

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, McGill University and Lady Davis Institute for Medical Research, Sir Mortimer B Davis-Jewish General Hospital, Montreal, Quebec, Canada

    David Hamilton

  2. Department of Experimental Medicine, McGill University and Lady Davis Institute for Medical Research, Sir Mortimer B Davis-Jewish General Hospital, Montreal, Quebec, Canada

    Nasser Fotouhi-Ardakani

  3. The Center for Translational Research in Cancer, McGill University and Lady Davis Institute for Medical Research, Sir Mortimer B Davis-Jewish General Hospital, Montreal, Quebec, Canada

    Gerald Batist

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  2. Nasser Fotouhi-Ardakani
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  3. Gerald Batist
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Editors and Affiliations

  1. MD Anderson Cancer Center, Houston, Texas, USA

    Borje Andersson M.D., Ph.D

  2. Cross Cancer Institute, Edmonton, Alberta, Canada

    David Murray Ph.D

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© 2002 Springer Science+Business Media New York

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Hamilton, D., Fotouhi-Ardakani, N., Batist, G. (2002). The Glutathione System in Alkylator Resistance. In: Andersson, B., Murray, D. (eds) Clinically Relevant Resistance in Cancer Chemotherapy. Cancer Treatment and Research, vol 112. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1173-1_4

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  • DOI: https://doi.org/10.1007/978-1-4615-1173-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5428-4

  • Online ISBN: 978-1-4615-1173-1

  • eBook Packages: Springer Book Archive

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