Modification of Radiosensitivity Following Chemotherapy Exposure: Potential Implications for Combined-Modality Therapy

  • Richard A. Britten
Part of the Cancer Treatment and Research book series (CTAR, volume 112)


Treatment protocols for many tumor sites often consist of a combination of poly-chemotherapy with loco-regional radiotherapy. In many instances, these treatments are given in close temporal proximity to each other, either within a few hours (concomitant) or within a few weeks of each other (sequential). In other instances, radiotherapy may be given at some considerable time after completion of chemotherapy to achieve a measure of loco-regional control in tumors that have recurred following front-line chemotherapy. The optimum integration of chemotherapy and radiotherapy in all three situations has yet to be fully established. Careful consideration of the impact of clinically relevant chemoresistance on radiation response in these various scenarios, and appropriate adjustments, may lead to qualitative differences in patient quality of life, and hopefully quantitative improvements in disease free survival


Cervical Cancer Radiation Response Small Cell Lung Cancer Cell Combine Modality Therapy Human Ovarian Cancer Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Richard A. Britten
    • 1
  1. 1.Department of Radiation OncologyEastern Virginia Medical SchoolNorfolkUSA

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