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Mechanisms of Drug Resistance in AML

  • Michael Andreeff
  • Marina Konopleva
Part of the Cancer Treatment and Research book series (CTAR, volume 112)

Abstract

The acute myelogenous leukemias (AML) are diverse in their clinical presentation, molecular, biological and immunological characteristics, and response to therapies. They encompass a wide spectrum of clinical features, developing slowly from myelodysplastic syndromes (MDS) or presenting with dramatic clinical features without prior warning, such as high circulating blast count resulting in leucostastis and bleeding, coagulopathies, cutaneous and organ infiltration, sepsis due to neutropenia, and anemia. Morphological classification was initially codified in the French-American-British (FAB) system1 and was recently modified in the World Health Organization (WHO) system.2 The leukemic transformation is believed to occur at an early stem cell level, based on the ability of CD34+38-leukemic cells to repopulate NOD/scid mice3 with the exception of acute promyelocytic leukemias (APL) that probably originate in CD34-33+cells. However, leukemic cells were recently reported to reside in the pre-CD34 “side-population” (SP) cell population,4 suggesting an even more primitive cell of origin

Keywords

Acute Myeloid Leukemia Acute Promyelocytic Leukemia Acute Myelogenous Leukemia Multi Drug Resistance Complete Remission Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Michael Andreeff
    • 1
  • Marina Konopleva
    • 1
  1. 1.Section of Molecular Hematology and Therapy Department of Blood and Marrow TransplantationThe University of Texas MD Anderson Cancer CenterTexasUSA

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