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Model Studies of Cyclophosphamide Resistance in Human Myeloid Leukemia

  • Borje S. Andersson
  • David Murray
Part of the Cancer Treatment and Research book series (CTAR, volume 112)

Abstract

Cyclophosphamide (CP), 4-hydroperoxycyclophosphamide (4HC), mafosfamide, and ifosphamide are antineoplastic alkylating agents collectively referred to as oxazaphosphorines. Oxazaphosphorines are used in the treatment of many types of cancer, including neo-adjuvant, adjuvant and high-dose treatment for breast tumors, salvage chemotherapy for a variety of solid tumors, and high-dose conditioning therapy of patients undergoing hematopoietic stem cell transplantation1, 2. In the latter context, these drugs are widely used for the treatment of myeloid leukemias, which represent the focus of this chapter

Keywords

Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Nucleotide Excision Repair Aldehyde Dehydrogenase Xeroderma Pigmentosum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Borje S. Andersson
    • 1
  • David Murray
    • 2
  1. 1.Department of Blood and Marrow TransplantationThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Division of Experimental Oncology, Department of OncologyUniversity of Alberta and Department of Experimental OncologyAlbertaCanada

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