PPARγ Mechanism of Action Studies

  • Steven Kliewer
Part of the Medical Science Symposia Series book series (MSSS, volume 18)


Adult onset (Type 2) diabetes mellitus afflicts more than 100 million people worldwide, and its prevalence is soaring in developed countries with high fat diets and increasingly sedentary lifestyles. The development of insulin resistance is an early step in the onset of Type 2 diabetes. The glitazones, including rosiglitazone and pioglitazone, and tyrosine analogs GI262570 and GW1929 are promising new drugs for the treatment of Type 2 diabetes [1]. These drugs improve insulin sensitivity and reduce glucose levels in Type 2 diabetics by increasing glucose utilization in muscle and decreasing glucose production in the liver [2]. These drugs have the added therapeutic benefits of increasing high density lipoprotein cholesterol levels and decreasing triglyceride and free fatty acid (FFA) levels.


White Adipose Tissue Pyruvate Carboxylase High Density Lipoprotein Cholesterol Level Fatty Acid Transport Increase Glucose Utilization 
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© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Steven Kliewer

There are no affiliations available

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