PPARγ Mechanism of Action Studies
Adult onset (Type 2) diabetes mellitus afflicts more than 100 million people worldwide, and its prevalence is soaring in developed countries with high fat diets and increasingly sedentary lifestyles. The development of insulin resistance is an early step in the onset of Type 2 diabetes. The glitazones, including rosiglitazone and pioglitazone, and tyrosine analogs GI262570 and GW1929 are promising new drugs for the treatment of Type 2 diabetes . These drugs improve insulin sensitivity and reduce glucose levels in Type 2 diabetics by increasing glucose utilization in muscle and decreasing glucose production in the liver . These drugs have the added therapeutic benefits of increasing high density lipoprotein cholesterol levels and decreasing triglyceride and free fatty acid (FFA) levels.
KeywordsCholesterol Carbohydrate Tyrosine Citrate Lipase
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- 5.Way JM, Harrington WW, Brown KK, et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 2001;142:1269–77.PubMedCrossRefGoogle Scholar