Abstract
Activators of PPARĪ± have direct anti-inflammatory properties in the artery wall. They also have indirect anti-inflammatory effects by virtue of their ability to increase the plasma concentration of the anti-inflammatory high density lipoproteins (HDL).
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Cockerill GW, Rye K-A, Gamble JR, Vadas MA, Barter PJ. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arterioscler Thromb Vasc Biol 1995;15:1987ā94.
Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362:801ā9.
Klein C, Kohler H, Bittinger F, et al. Comparative studies on vascular endothelium in vitro. I. Cytokine effects on the expression of adhesion molecules by human umbilical vein, saphenous vein and femoral artery endothelial cells. Pathobiology 1994;62:199ā208.
Faull RJ. Adhesion molecules in health and disease. Aust NZ J Med 1995;25:720ā30.
Peter K, Nawroth P, Condradt C, et al. Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intracellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin. Arterioscler Thromb Vasc Biol 1997; 17:505ā12.
Rohde LE, Lee RT, Rivero J, et al. Circulation cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arterioscler Thromb Vasc Biol 1998;18:1765ā70.
Morisaki N, Saito I, Tamura K, et al. New indices of ischemic heart disease and aging: Studies on the serum levels of soluble intracellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis 1997;131:43ā48.
Ridker PM, Hennekens CH, Roitman-Johnson B, Stampfer MJ, Allen J. Plasma concentration of soluble intracellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men. Lancet 1998;351:88ā92.
Li H, Cybulsky MI, Gimbrone MA, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993;13:197ā204.
Sakai A, Kume N, Nishi E, Tanoue K, Miyasaka M, Kita T. P-Selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimai accumulation of macrophages and T lymphocytes. Arterioscler Thromb Vasc Biol 1997;17:310ā16.
Richardson M, Hadcock SJ, DeReske M, Cybulsky MI. Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler Thromb 1994;14:760ā69.
12. Clay MA, Pyle DH, Rye K-A, Vadas MA, Gamble JR, Barter PJ. Time sequence of the inhibition of endothelial adhesion molecule expression by reconstituted high density lipoproteins. Atherosclerosis 2001; in press.
Ashby DT, Rye K-A, Clay MA, Vadas MA, Gamble JR, Barter PJ. Factors influencing the ability of high density lipoproteins to inhibit the expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler Thromb Vasc Biol 1998;18:1450ā55.
Ashby D, Gamble J, Vadas M, et al. Lack of effect of serum amyloid A (SAA) on the ability of high density lipoproteins to inhibit endothelial cell adhesion molecule expression. Atherosclerosis 2001; 154:113ā21.
Baker PW, Rye KA, Gamble JR, Vadas MA, Barter P.J. Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells. J Lipid Res 1999:40:345-53.
Baker PW, Rye KA, Gamble JR, Vadas MA, Barter PJ. Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression. J Lipid Res 2000;41:1261ā67.
Bagdade JD, Buchanan WF, Pollare T, Lithell H. Abnormal lipoprotein phospholipid composition in patients with essential hypertension. Atherosclerosis 1995; 117:209ā15.
Subbaiah PV, Haydn Pritchard P. Molecular species of phosphatidylcholine in familial lecithin-cholesterol acyltransferase deficiency: Effect of enzyme supplementation. Biochim et Biophys Acta 1989;1003:145ā50.
Mackness MI, Abbott C, Arrol S, Durrington PN. The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochem J 1993;294:829ā34.
Yoshikawa M, Sakuma N, Hibino T, Sato T, Fujinami T. HDL3 exerts more powerful antioxidative, protective effects against copper-catalyzed LDL oxidation than HDL2. Clin Biochem 1997;30:221ā25.
Garner B, Waldeck AR, Witting PK, Rye K-A, Stocker R. Oxidation of high density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins A-I and A-II. J Biol Chem 1998:273;6088ā95.
Xia P, Gamble JR, Rye K-A, et al. Tumor necrosis factor Ī± induces adhesion molecule expression through the sphingosine kinase pathway. Proc Nat Acad Sci USA 1998;95: 14196ā201.
Xia P, Vadas MA, Rye K-A, Barter PJ, Gamble JR. High density lipoproteins (HDL) interupt the sphingosine kinase signalling pathway. J Biol Chem 1999;274:33143ā47.
Cercek B. Reconstituted HDL containing human apolipoprotein A-I reduces VCAM-1 expression and neointima formation following periadventitial cuff-induced carotid injury in apoE null mice. Biochem Biophys Res Comm 1999;264:465ā68.
Cockerill GW, Huehns TY, Weerasinghe A, et al. Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation. Circulation 2001;103:108ā12.
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Barter, P., Baker, P., Gamble, J., Vadas, M., Rye, KA. (2002). Anti-Inflammatory Properties of High Density Lipoproteins. In: Fruchart, JC., Gotto, A.M., Paoletti, R., Staels, B., Catapano, A.L. (eds) Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications. Medical Science Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1171-7_13
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DOI: https://doi.org/10.1007/978-1-4615-1171-7_13
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