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Current Methods for Cognitive Neuroanatomy

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Experimental Methods in Neuropsychology

Part of the book series: Neuropsychology and Cognition ((NPCO,volume 21))

Abstract

Neuropsychology has long relied on lesion studies and one of the main attempts of neuropsychologists was to study the interrelationships between brain lesions and concomitant behavioural changes. With the advent of new methods which are now available for neuropsychological or neurological research, the focus has been changed considerably. Besides the fact that there is a kind of reorientation in neuropsychology there are also new fields coming into play. One of these new fields involves the analysis of relationships between brain structure and function in humans, a research field which has been entitled as “Cognitive Neuroanatomy” by Sandra Witelson (1992). While in the beginning, researchers looked for structure-function relationships by analysing various parts of post mortem brains, the tremendous pace of development in brain imaging technologies has revolutionised our ability to investigate brain structure and function. Techniques are now available to capture features of the anatomy and function of whole brain scales, mapping neuronal dynamics and gene expression as well as growth and degeneration processes that span multi-layer time scales both for post mortem and in vivo cases. The number of brain imaging investigations is also increasing exponentially. A major goal of these new studies is to analyse how the whole brain or parts of it varies across age, gender, disease, in large human populations, due to external stimulation, or whether there are between-hemisphere differences.

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Reference List

  • Aboitiz, F., Scheibel, A. B., and Zaidel, E. “Morphometry of the Sylvian fissure and the corpus callosum, with emphasis on sex differences.” Brain 115 (1992): 1521–1541.

    Article  PubMed  Google Scholar 

  • Allen, L. S., Richey, M., Chai, Y., and Gorski, R. “Sex differences in the cerebral cortex and the corpus callosum of the living human being.” Journal of Neuroscience 11 (1991): 933–942.

    PubMed  Google Scholar 

  • Amunts, K., Jäncke, L., Mohlberg, H., Steinmetz, H., and Zilles, K. “Interhemispheric asymmetry of the human motor cortex related to handedness and gender.” Neuropsychologia 38 (2000a): 304–312.

    Article  Google Scholar 

  • Amunts, K., Malikovic, A., Mohlberg, H., Schormann, T., and Zilles, K. “Brodmann’s areas 17 and 18 brought into stereotaxic space-where and how variable?” Neuroimage 11 (2000b): 66–84.

    Article  Google Scholar 

  • Amunts, K., Schlaug, G., Jäncke, L., Steinmetz, H., Schleicher, A., and Zilles, K. “Hand skills covary with the size of motor cortex: a macrostructural adaptation.” Human Brain Mapping 5 (1997): 206–215.

    Article  PubMed  Google Scholar 

  • Amunts, K., Schleicher, A., Burgel, U., Mohlberg, H., Uylings, H. B., and Zilles, K. “Broca’s region revisited: cytoarchitecture and intersubject variability.” Journal of Comparative Neurolology 412 (1999): 319–341.

    Article  Google Scholar 

  • Appel, F. W. and Appel, E. M. “Intracranial variation in the weight of the human brain.” Human Biology 14(1942): 235–250.

    Google Scholar 

  • Arndt, S., Swayze, V., Cizadlo, T., O’Leary, D., Cohen, G., Yuh, W. T., Ehrhardt, J. C., and Andreasen, N. C. “Evaluating and validating two methods for estimating brain structure volumes: tessellation and simple pixel counting.” Neuroimage 1 (1994): 191–198.

    Article  PubMed  Google Scholar 

  • Ashburner, J., Andersson, J. L., and Friston, K. J. “Image registration using a symmetric prior-in three dimensions.” Human Brain Mapping 9 (2000): 212–225.

    Article  PubMed  Google Scholar 

  • Bonin, von, G. “Anatomical asymmetries of the cerebral hemispheres.” In Interhemispheric relations and cerebral dominance, edited by V.B. Mountcastle, (pp. 1–6). Baltimore: Johns Hopkins Press, 1962.

    Google Scholar 

  • Caviness, V. S., Jr., Kennedy, D. N., Richelme, C., Rademacher, J., and Filipek, P. A. “The human brain age 7–11 years: a volumetric analysis based on magnetic resonance images.” Cerebral Cortex 6 (1996): 726–736.

    Article  PubMed  Google Scholar 

  • Collins, D. L., Neelin, P., Peters, T. M., and Evans, A. C. “Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space.” Journal of Computer Assisted Tomography 18 (1994): 192–205.

    Article  PubMed  Google Scholar 

  • Csernansky, J. G., Joshi, S., Wang, L., Haller, J. W., Gado, M., Miller, J. P., Grenander, U., and Miller, M. I. “Hippocampal morphometry in schizophrenia by high dimensional brain mapping.” Proceedings of the National Academy of Sciences U.S.A 95 (1998): 11406–11411.

    Article  Google Scholar 

  • Cunningham, D. J. “Contribution to the surface anatomy of the cerebral hemispheres.” The Academy House (1892): 77–160.

    Google Scholar 

  • Davatzikos, C. and Resnick, S. M. “Sex differences in anatomic measures of interhemispheric connectivity: correlations with cognition in women but not men.” Cerebral Cortex 8 (1998): 635–640.

    Article  PubMed  Google Scholar 

  • De Lacoste-Utamsing, M. C. and Holloway, R. L. “Sexual dimorphism in the human corpus callosum.” Science 216 (1982): 1431–1432.

    Article  Google Scholar 

  • De Lacoste, M. C., Adesanya, T., and Woodward, D. J. “Measures of gender differences in human brain and their relationship to brain weight.” Biological Psychiatry 28 (1990): 931–942.

    Article  PubMed  Google Scholar 

  • Denenberg, V. H., Cowell, P. E., Fitch, R., Kertesz, A., and Kenner, G. H. (1991). Corpus callosum: multiple parameter measurements in rodents and humans. Physiology and Behavior, 49 433–437.

    Article  PubMed  Google Scholar 

  • Eberstaller, O. “Zur Oberflächenanatomie der Grosshirn-Hemisphären. Vorläufige Mitteilung. Das untere Scheitelläppchen.” Wiener Medizinische Blätter 21 (1884): 644–646.

    Google Scholar 

  • Eberstaller, O. Das Stirnhirn. Ein Beitrag zur Anatomie der Oberfläche des Grosshirns. Wien: Urban and Schwarzenberg, 1890.

    Google Scholar 

  • Economo Cv and Horn, L. “Über Windungsrelief, Maße und Rindenarchitektonik der Supratemporalfläche, ihre individuellen und ihre Seitenunterschiede.” Zeitschrift für Neurologie und Psychiatrie 130 (1930): 678–757.

    Article  Google Scholar 

  • Evans, A. C., Collins, D. L., Mills, S. R., Brown, E. D., Kelly, R. L., and Peters, T. M. “3D Statistical neuroanatomical models from 305 MRI volumes.” Proc.IEEE-Nuclear Science Symposium and Medical Imaging (1993): 1813–1817.

    Google Scholar 

  • Flechsig, P. “Bemerkungen über die Hörsphäre des menschlichen Gehirns.” Zentralblatt 21 (1908): 61–67.

    Google Scholar 

  • Fox, P. T., Perlmutter, J. S., and Raichle, M. E. “A stereotactic method of anatomical localization for positron emission tomography.” Journal of Computer Assisted Tomography 9 (1985): 141–153.

    Article  PubMed  Google Scholar 

  • Friston, K. J., Frith, C. D., Liddle, P. F., and Frackowiak, R. S. “Plastic transformation of PET images.” Journal of Computer Assisted Tomography 15 (1991): 634–639.

    Article  PubMed  Google Scholar 

  • Galaburda, A. M., Corsiglia, J., Rosen, G. D., and Sherman, G. F. “Planum temporale asymmetry, reappraisal since Geschwind and Levitsky.” Neuropsychologia 25 (1987): 853–868.

    Article  Google Scholar 

  • Gaser, C., Volz, H. P., Kiebel, S., Riehemann, S., and Sauer, H. “Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research.” Neuroimage 10 (1999): 107–113.

    Article  PubMed  Google Scholar 

  • Geschwind, N. and Levitsky, W. “Human brain: left-right asymmetries in temporal speech region.” Science 161 (1968): 186–187.

    Article  PubMed  Google Scholar 

  • Geyer, S., Ledberg, A., Schleicher, A., Kinomura, S., Schormann, T., Burgel, U., Klingberg, T., Larsson, J., Zilles, K., and Roland, P. E. “Two different areas within the primary motor cortex of man.” Nature 382 (1996): 805–807.

    Article  PubMed  Google Scholar 

  • Geyer, S., Schleicher, A., and Zilles, K. “Areas 3a, 3b, and 1 of human primary somatosensory cortex.” Neuroimage 10 (1999): 63–83.

    Article  PubMed  Google Scholar 

  • Goldstein, J. M., Goodman, J. M., Seidman, L. J., Kennedy, D. N., Makris, N., Lee, H., Tourville, J., Caviness, V. S. J., Faraone, S. V., and Tsuang, M. T. “Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging.” Archives of Genearal Psychiatry 56 (1999): 537–547.

    Article  Google Scholar 

  • Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., and Gur, R. E. “Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance.” Journal of Neuroscience 19 (1999): 4065–4072.

    PubMed  Google Scholar 

  • Hellige, J. B., Taylor, K. B., Lesmes, L., and Peterson, S. “Relationships between brain morphology and behavioral measures of hemispheric asymmetry and interhemispheric interaction.” Brain and Cognition 36 (1998): 158–192.

    Article  PubMed  Google Scholar 

  • Höhne, K. H., Petersik, A., Pflesser, B., Pommert, A., Priesmeyer, K., Riemer, M., Schubert, M., Schiemann, T., Tiede, U., Urban, M., Frederking.H., Lowndes, M., and Morris, J. VOXEL-MAN 3D Navigator: Brain and Skull. Regional, Functional and Radiological Anatomy . Springer-Verlag Electronic Media: Springer-Verlag Electronic Media, 2001.

    Google Scholar 

  • Ide, A., Rodriguez, E., Zaidel, E., and Aboitiz, F. “Bifurcation patterns in the human sylvian fissure: hemispheric and sex differences.” Cerebral Cortex 6 (1996): 717–725.

    Article  PubMed  Google Scholar 

  • Ide, A., Dolezal, C., Fernandez, M., Labbe, E., Mandujano, R., Montes, S., Segura, P., Verschae, G., Yarmuch, P., and Aboitiz, F. “Hemispheric differences in variability of fissural patterns in parasylvian and cingulate regions of human brains.” Journal Comparative Neurology 410 (1999): 235–242.

    Article  Google Scholar 

  • Jäncke, L., Preis, S., and Steinmetz, H. “The relation between forebrain volume and midsagittal size of the corpus callosum in children”. Neuroreport 10 (1999): 2981–2985.

    Article  PubMed  Google Scholar 

  • Jäncke, L., Schlaug, G., Huang, Y., and Steinmetz, H. “Asymmetry of the planum parietale.” NeuroReport 5 (1994): 1161–1163.

    Article  PubMed  Google Scholar 

  • Jäncke, L., Staiger, J. F., Schlaug, G., Huang, Y., and Steinmetz, H. “The relationship between corpus callosum size and forebrain volume.” Cerebral Cortex 7 (1997): 48–56.

    Article  PubMed  Google Scholar 

  • Kennedy, D. N., Lange, N., Makris, N., Bates, J., Meyer, J., and Caviness, V. S. J. “Gyri of the human neocortex: an MRI-based analysis of volume and variance.” Cerebral Cortex 8 (1998): 372–384.

    Article  PubMed  Google Scholar 

  • Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S., and Frith, C. D. “Navigation-related structural change in the hippocampi of taxi drivers.” Proceedings of the National Acadamey of Sciences U.S.A 97 (2000): 4398–4403.

    Article  Google Scholar 

  • May, A., Ashburner, J., Buchel, C., McGonigle, D. J., Friston, K. J., Frackowiak, R. S., and Goadsby, P. J. “Correlation between structural and functional changes in brain in an idiopathic headache syndrome”. Nature Medicine 5 (1999): 836–838.

    Article  PubMed  Google Scholar 

  • Narr, K., Thompson, P., Sharma, T., Moussai, J., Zoumalan, C., Rayman, J., and Toga, A. “Three-dimensional mapping of gyral shape and cortical surface asymmetries in schizophrenia: gender effects.” American Journal of Psychiatry 158 (2001): 244–255.

    Article  PubMed  Google Scholar 

  • Narr, K. L., Thompson, P. M., Sharma, T., Moussai, J., Cannestra, A. F., and Toga, A. W. “Mapping morphology of the corpus callosum in schizophrenia.” Cerebral Cortex 10 (2000): 40–49.

    Article  PubMed  Google Scholar 

  • Nowinski, W. L., Thirunavuukaresuu, A., and Kennedy, D. N. Brain atlas for functional imaging. Thieme Verlag. CD. 2001.

    Google Scholar 

  • Penhune, V. B., Zatorre, R. J., MacDonald, J. D., and Evans, A. C. “Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans.” Cerebral Cortex 6 (1996): 661–672.

    Article  PubMed  Google Scholar 

  • Peters, M., Oeltze, S., Seminowicz, D., Steinmetz, H., Koeneke, S., and Jäncke, L. Subdivision of the Corpus Callosum into subregions. Brain and Cognition (in press, 2002).

    Google Scholar 

  • Peters, M., Jäncke, L., and Zilles, K. “Comparison of overall brain volume and midsagittal corpus callosum surface area as obtained from NMR scans and direct anatomical measures: a within-subject study on autopsy brains.” Neuropsychologia 38 (2000): 1375–1381.

    Article  PubMed  Google Scholar 

  • Pfeifer, R. A. “Myelogenetisch-anatomische Untersuchungen über das kortikale Ende der Hörleitung.” Leipzigs (1920): -54.

    Google Scholar 

  • Pfeifer, R. A. “Pathologie der Hörstrahlung und der corticalen Hörsphäre.” In Handbuch der Neurologie, edited by O. Bumke and O. Förster. Berlin: Springer-Verlag, 1936.

    Google Scholar 

  • Pruessner, J. C., Li, L. M., Serles, W., Pruessner, M., Collins, D. L., Kabani, N., Lupien, S., and Evans, A. C. “Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories.” Cerebral Cortex 10 (2000): 433−442.

    Article  PubMed  Google Scholar 

  • Rademacher, J., Galaburda, A., Kennedy, D. N., Filipek, P. A., and Caviness, V. S. J. “Human cerebral cortex: localization, parcellation, and morphometry with magnetic resonance imaging.” Journal of Cognitive Neuroscience 4 (1992): 352−374.

    Article  Google Scholar 

  • Rademacher, J., Morosan, P., Schormann, T., Schleicher, A., Werner, C, Freund, H. J., and Zilles, K. “Probabilistic mapping and volume measurement of human primary auditory cortex.” Neuroimage 13 (2001): 669−683.

    PubMed  Google Scholar 

  • Ringo, J. L., Doty, R. W., Demeter, S., and Simard, P. Y. “Time is of the essence: A conjecture that hemispheric specialization arises from interhemispheric conduction delay.” Cerebral Cortex 4 (1994): 331−343.

    Article  PubMed  Google Scholar 

  • Rubens, A. B., Mahowald, M. W., and Hutton, J. T. “Asymmetry of the lateral (sylvian) fissures in man.” Neurology 26 (1976): 620−624.

    Article  PubMed  Google Scholar 

  • Schlaug, G., Jancke, L., Huang, Y., and Steinmetz, H. “In vivo evidence of structural brain asymmetry in musicians”. Science 267 (1995): 699−701.

    Article  PubMed  Google Scholar 

  • Shapleske, J., Rossell, S. L., Woodruff, P. W., and David, A. S. “The planum temporale: a systematic, quantitative review of its structural, functional and clinical significance.” Brain Research Brain Research Review 29 (1999): 26−49.

    Article  Google Scholar 

  • Small, C. S. and Peterson, D. I. “The reliability of dimensions of formalin-fixed brains.” Neurology 32 (1982): 413−415.

    Article  PubMed  Google Scholar 

  • Steinmetz, H., Furst, G., and Freund, H. J. “Cerebral cortical localization: application and validation of the proportional grid system in MR imaging.” Journal of Computer Assisted Tomography 13 (1989): 10–19.

    Article  PubMed  Google Scholar 

  • Steinmetz, H., Furst, G., and Freund, H. J. “Variation of perisylvian and calcarine anatomic landmarks within stereotaxic proportional coordinates.” American Journal of Neuroradiology 11 (1990a): 1123–1130.

    Google Scholar 

  • Steinmetz, H., Rademacher, J., Jäncke, L., Huang, Y. X., Thron, A., and Zilles, K. “Total surface of temporoparietal intrasylvian cortex: diverging left- right asymmetries.” Brain and Language 39 (1990b): 357–372.

    Article  Google Scholar 

  • Steinmetz, H. and Galaburda, A. M. “Planum temporale asymmetry: in-vivo morphometry affords a new perspective for neuro-behavioral research.” Reading and Writing: An Interdisciplinary Journal 3 (1991a): 331–343.

    Article  Google Scholar 

  • Steinmetz, H., Volkmann, J., Jäncke, L., and Freund, H. J. “Anatomical left-right asymmetry of language-related temporal cortex is different in left- and right-handers.” Annals of Neurology 29 (1991b): 315–319.

    Article  Google Scholar 

  • Steinmetz, H. “Structure, function, and cerebral asymmetry: in vivo morphometry of the planum temporale.” Neuroscience and Biobehavioral Reviews 20 (1996): 587–591.

    Article  PubMed  Google Scholar 

  • Talairach, J. and Tournoux, P. Co-Planar stereotaxic atlas of the human brain. 3-Dimensional proportional system: an approach to cerebral imaging. New York: Thieme Medical Publishers, Inc, 1988.

    Google Scholar 

  • Thompson, P. M., Giedd, J. N., Woods, R. P., MacDonald, D., Evans, A. C., and Toga, A. W. “Growth patterns in the developing brain detected by using continuum mechanical tensor maps.” Nature 404 (2000): 190–193.

    Article  PubMed  Google Scholar 

  • Thompson, P. M., Moussai, J., Zohoori, S., Goldkorn, A., Khan, A. A., Mega, M. S., Small, G. W., Cummings, J. L., and Toga, A. W. “Cortical variability and asymmetry in normal aging and Alzheimer’s disease.” Cerebral Cortex 8 (1998): 492–509.

    Article  PubMed  Google Scholar 

  • Thompson, P. M., Schwartz, C., Lin, R. T., Khan, A. A., and Toga, A. W. “Three-dimensional statistical analysis of sulcal variability in the human brain.” Journal of Neuroscience 16 (1996): 4261–4274.

    PubMed  Google Scholar 

  • Thompson, P. M. and Toga, A. W. Brain warping . Academic Press, 1999.

    Google Scholar 

  • Westbury, C. F., Zatorre, R. J., and Evans, A. C. “Quantifying variability in the planum temporale: a probability map.” Cerebral Cortex 9 (1999): 392–405.

    Article  PubMed  Google Scholar 

  • Witelson, S. F. “Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study.” Brain 112 (1989): 799–835.

    Article  PubMed  Google Scholar 

  • Witelson, S. F. “Cognitive neuroanatomy: a new era” [editorial; comment]. Neurology 42 (1992): 709–713.

    Article  PubMed  Google Scholar 

  • Witelson, S. F. and Kigar, D. L. “Sylvian fissure morphology and asymmetry in men and women: bilateral differences in relation to handedness in men.” Journal of Comparative Neurology 323 (1992): 326–340.

    Article  PubMed  Google Scholar 

  • Wright, I. C, McGuire, P. K., Poline, J. B., Travere, J. M., Murray, R. M., Frith, C. D., Frackowiak, R. S., and Friston, K. J. “A voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia.” Neuroimage 2 (1995): 244–252.

    Article  PubMed  Google Scholar 

  • Yousry, T. A., Schmid, U. D., Alkadhi, H., Schmidt, D., Peraud, A., Buettner, A., and Winkler, P. Localization of the motor hand area to a knob on the precentral gyrus. Brain 120 (1997): 141–157.

    Article  PubMed  Google Scholar 

  • Yucel, M., Stuart, G. W., Maruff, P., Velakoulis, D., Crowe, S. F., Savage, G., and Pantelis, C. “Hemispheric and gender-related differences in the gross morphology of the anterior cingulate/paracingulate cortex in normal volunteers: an MRI morphometric study.” Cerebral Cortex 11 (2001): 17–25.

    Article  PubMed  Google Scholar 

  • Zilles, K., Kawashima, R., Dabringhaus, A., Fukuda, H., and Schormann, T. “Hemispheric shape of european and Japanese brains: 3-D MRI analysis of intersubject variability, ethnical, and gender differences.” Neuroimage 13 (2001): 262–271.

    Article  PubMed  Google Scholar 

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Jäncke, L. (2003). Current Methods for Cognitive Neuroanatomy. In: Hugdahl, K. (eds) Experimental Methods in Neuropsychology. Neuropsychology and Cognition, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1163-2_9

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