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The Expanded Poly-Q Length Within AR and AR Coregulator AIB1 and Their Clinical Implications

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Androgens and Androgen Receptor

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Abstract

The cloning of the androgen receptor gene in 1988 (Chang et al., 1988) and identification of androgen receptor (AR) coactivators have greatly improved our understanding of intracellular androgenic action and the role of androgenicity in many androgen-dependent disorders.

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References

  • Abdullah, A., Trifiro, M.A., Panet-Raymond, V., Alvarado, C., de Tourreil, S., Frankel, D., Schipper and H.M., Pinsky, L. Spinobulbar muscular atrophy: polyglutamine-expanded androgen receptor is proteolytically resistant in vitro and processed abnormally in transfected cells. Hum Mol Genet 1998; 7: 379–384.

    Article  PubMed  CAS  Google Scholar 

  • Adachi, H., Kume, A., Li, M., Nakagomi, Y., Niwa, H., Do, J., Sang, C, Kobayashi, Y., Doyu, M. and Sobue, G. Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death. Hum. Mol. Genet. 2001; 10: 1039–1048.

    Article  PubMed  CAS  Google Scholar 

  • Anzick, S.L., Kononen, J., Walker, R.L., Azorsa, D.O., Tanner, M.M., Guan, X.Y., Sauter, G., Kallioniemi, O.P., Trent, J.M. and Meltzer, P.S. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997; 277: 965–968.

    Article  PubMed  CAS  Google Scholar 

  • Beilin, J., Harewood, L., Frydenberg, M., Mameghan, M., Martyres, R.F., Farish, S.J., Yue, C, Deam, D.R., Byron, K.A. and Zajac, J.D. A case-control study of the androgen gene CAG repeat polymorphism in Australian prostate carcinoma subjects. Cancer 2001; 92: 941–949.

    Article  PubMed  CAS  Google Scholar 

  • Brinkmann, A.O. Molecular basis of androgen insensitivity. Mol. Cell. Endocrinol. 2001; 179: 105–109.

    Article  Google Scholar 

  • Brinkmann, A.O. Molecular basis of androgen insensitivity. Mol. Cell. Endocrinol. 2001; 179: 105–109.

    Article  PubMed  CAS  Google Scholar 

  • Brooks, B.P. and Fischbeck, K.H.. Spinal and bulbar muscular atrophy: a trinucleotide-repeat expansion neurodegenerative disease. Trends Neurosci. 1995; 18: 459–461.

    Article  PubMed  CAS  Google Scholar 

  • Casella, R., Maduro, M.R., Lipshultz, L.I. and Lamb, D.J. Significance of the polyglutamine tract polymorphism in the androgen receptor. Urology 2001; 58:651–656.

    Article  PubMed  CAS  Google Scholar 

  • Chamberlain, N.L., Driver, E.D. and Miesfeld, R.L. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res.. 1994; 22: 3181–3186.

    Article  PubMed  CAS  Google Scholar 

  • Chang,C.S., Kokontis, J. and Liao, S.T. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 1988; 240: 324–326.

    Article  PubMed  CAS  Google Scholar 

  • Correa-Cerro, L., Wohr, G., Haussler, J., Berthon, P., Drelon, E., Mangin, P., Fournier, G., Cussenot, O, Kraus, P., Just, W., Paiss, T., Cantu, J.M. and Vogel, W. (CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French-German population. Eur. J. Hum. Genet. 1999; 7: 357–362.

    Article  PubMed  CAS  Google Scholar 

  • Culig, Z., Hobisch, A., Bartsch, G. and Klocker, H. Androgen receptor-an update of mechanisms of action in prostate cancer. Urol. Res. 2000a; 28: 211–219.

    Article  CAS  Google Scholar 

  • Culig, Z., Hobisch, A., Bartsch, G. and Klocker, H. Expression and function of androgen receptor in carcinoma of the prostate. Microsc. Res. Tech. 2000b; 51: 447–55.

    Article  CAS  Google Scholar 

  • Dadze, S., Wieland, C., Jakubiczka, S., Funke, K., Schroder, E., Royer-Pokora, B., Willers, R. and Wieacker, P.F. The size of the CAG repeat in exon 1 of the androgen receptor gene shows no significant relationship to impaired spermatogenesis in an infertile Caucasoid sample of German origin. Mol. Hum. Reprod. 2000; 6: 207–214.

    Article  PubMed  CAS  Google Scholar 

  • Dunning, A.M., McBride, S., Gregory, J., Durocher, F., Foster, N.A., Healey, C.S., Smith, N., Pharoah, P.D., Luben, R.N., Easton, D.F. and Ponder, B.A No association between androgen or vitamin D receptor gene polymorphisms and risk of breast cancer. Carcinogenesis 1999; 20: 2131–2135.

    Article  PubMed  CAS  Google Scholar 

  • Doyu, M., Sobue, G., Kimata, K., Yamamoto, K. and Mitsuma, T. Androgen receptor mRNA with increased size of tandem CAG repeat is widely expressed in the neural and nonneural tissues of X-linked recessive bulbospinal neuronopathy. J. Neurol. Sci. 1994; 127: 43–47.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, S.M., Badzioch, M.D., Minter, R., Hamoudi, R., Collins, N., Ardern-Jones, A., Dowe, A., Osborne, S., Kelly, J., Shearer, R., Easton, D.F., Saunders, G.F., Dearnaley, D.P. and Eeles, R.A Androgen receptor polymorphisms: association with prostate cancer risk, relapse and overall survival. Int. J. Cancer. 1999; 84: 458–465.

    Article  PubMed  CAS  Google Scholar 

  • Giguere, Y., Dewailly, E., Brisson, J., Ayotte, P., Laflamme, N., Demers, A., Forest, V.I., Dodin, S., Robert, J. and Rousseau, F. Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population. Cancer Res. 2001; 61: 5869–5874.

    PubMed  CAS  Google Scholar 

  • Giovannucci, E., Stampfer, M.J., Krithivas, K., et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc. Natl. Acad. Sci. USA 1997; 94: 3320–3323.

    Article  PubMed  CAS  Google Scholar 

  • Giovannucci, E., Stampfer, M.J., Chan, A., Krithivas, K., Gann, P.H., Hennekens, C.H. and Kantoff, P.W CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians. Prostate 1999; 39: 130–134.

    Article  PubMed  CAS  Google Scholar 

  • Giovannucci, E., Platz, E.A., Stampfer, M.J., Chan, A., Krithivas, K., Kawachi, I., Willett, W.C. and Kantoff, P.W The CAG repeat within the androgen receptor gene and benign prostatic hyperplasia. Urology 1999; 53:121–125.

    Article  PubMed  CAS  Google Scholar 

  • Gnanapragasam, V.J., Leung, H.Y., Pulimood, A.S., Neal, D.E. and Robson, C.N. Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br. J. Cancer 2001; 85: 1928–1936.

    Article  PubMed  CAS  Google Scholar 

  • Gnanapragasam, V.J., McCahy, P.J., Neal, D.E. and Robson, C.N. Insulin-like growth factor II and androgen receptor expression in the prostate. Br. J. Urol. Int. 2000; 86: 731–735.

    Article  CAS  Google Scholar 

  • Grossmann, M.E., Huang, H. and Tindall, D.J Androgen receptor signaling in androgen-refractory prostate cancer. J. Natl. Cancer Inst. 2001; 93: 1687–1697.

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb, B., Pinsky, L., Beitel, L.K. and Trifiro, M. Androgen insensitivity. Am. J. Med. Genet. 1999; 89: 210–217.

    Article  PubMed  CAS  Google Scholar 

  • Gregory, C.W., He, B., Johnson, R.T., Ford, O.H., Mohler, J.L., French, F.S. and Wilson, E.M. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy. Cancer Res. 2001; 61: 4315–4319.

    PubMed  CAS  Google Scholar 

  • Hall, R.E., Aspinall, J.O., Horsfall, D.J., Birrell, S.N., Bentel, J.M., Sutherland, R.L. and Tilley, W.D. Expression of the androgen receptor and an androgen-responsive protein, apolipoprotein D, in human breast cancer. Br. J. Cancer, 1996; 74: 1175–1180.

    Article  PubMed  CAS  Google Scholar 

  • Hardy, D.O., Scher, H.I., Bogenreider, T., Sabbatini, P., Zhang, Z.F., Nanus, D.M. and Catterall, J.F Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J. Clin. Endocrinol. Metab. 1996; 81: 4400–4405.

    Article  PubMed  CAS  Google Scholar 

  • Hickey, T., Chandy, A. and Norman, R.J. The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2002; 87:161–165.

    Article  PubMed  CAS  Google Scholar 

  • Hsing, A.W. Hormones and prostate cancer: What’s next? Epidemiol. Rev. 2001a; 23: 42–58.

    CAS  Google Scholar 

  • Hsing, A.W., Gao, Y-T., Wu, G., Wang, X., Deng, J., Sesterhenn, LA., Mostofi, K.F., Benchiou, J. and Chang, C. Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China. Cancer Res. 2000; 60: 5109–5114.

    Google Scholar 

  • Hsing, A.W. and Devesa, S.S. Trends and patterns in prostate cancer risk: what do they suggest? Epidemiol. Rev. 2001b; 23: 3–13.

    CAS  Google Scholar 

  • Hsing, A.W., Reichardt J., K. and Stanczyk, F.Z. Hormones and prostate cancer: current perspectives and future directions The Prostate 2002a; (in press)

    Google Scholar 

  • Hsing, A.W., Chokkalingam, A.P., Gao, Y.T., Wu, G., Wang, X., Deng, J.,Cheng, J., Sesterhenn, I.A., Mostofi, F.K., Chiang, T., Chen, Y.L., Stanczyk, F.Z. and Chang C. Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study. Cancer Epidemiol. Biomarkers Prev. 2002b; 11:337–341.

    CAS  Google Scholar 

  • Irvine, R.A., Yu, M.C., Ross, R.K. and Coetzee, G.A The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res. 1995; 55: 1937–1940.

    PubMed  CAS  Google Scholar 

  • Kadouri, L., Easton, D.F., Edwards, S., Hubert, A., Kote-Jarai, Z., Glaser, B., Durocher, F., Abeliovich, D., Peretz, T. and Eeles, R.A CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers. Br. J. Cancer 2001; 85: 36–40.

    Article  PubMed  CAS  Google Scholar 

  • Kantoff, P., Giovannucci, E. and Brown, M. The androgen receptor CAG repeat polymorphism and its relationship to prostate cancer. Biochim Biophys Acta 1998; 1378: Cl–5.

    Google Scholar 

  • Kawasaki, T., Ushiyama, T., Ueyama, H., Inoue, K., Mori, K., Ohkubo, I. and Hukuda, S. Polymorphic CAG repeats of the androgen receptor gene and rheumatoid arthritis. Ann. Rheum. Dis. 1999; 58: 500–502.

    Article  PubMed  CAS  Google Scholar 

  • King, B.L., Peng, H.Q., Goss, P., Huan, S., Bronson, D., Kacinski, B.M. and Hogg, D. Repeat expansion detection analysis of (CAG)n tracts in tumor cell lines, testicular tumors, and testicular cancer families. Cancer Res. 1997; 57: 209–214.

    PubMed  CAS  Google Scholar 

  • Lange, E.M., Chen, H., Brierley, K., Livermore, H., Wojno, K.J., Langefeld, CD., Lange, K. and Cooney, K.A The polymorphic exon 1 androgen receptor CAG repeat in men with a potential inherited predisposition to prostate cancer. Cancer Epidemiol. Biomarkers Prev. 2000; 9: 439–442.

    PubMed  CAS  Google Scholar 

  • Latil, A.G., Azzouzi, R., Cancel, G.S., Guillaume, E.C., Cochan-Priollet, B., Berthon, P.L. and Cussenot, O. Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways. Cancer 2001; 92: 1130–1137.

    Article  PubMed  CAS  Google Scholar 

  • Legius, E., Vanderschueren, D., Spiessens, C, D’Hooghe, T. and Matthijs, G. Association between CAG repeat number in the androgen receptor and male infertility in a Belgian study. Clin. Genet. 1999; (6): 166–167.

    Google Scholar 

  • Levine, D.A. and Boyd, J. The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. Cancer Res. 2001; 61: 908–911.

    PubMed  CAS  Google Scholar 

  • Lieberman, A.P. and Fischbeck, K.H. Triplet repeat expansion in neuromuscular disease. Muscle Nerve 2000; 843–850.

    Google Scholar 

  • MacLean, H.E., Chu, S., Joske, F., Warne, G.L. and Zajac, J.D. Androgen receptor binding studies on heterozygotes in a family with androgen insensitivity syndrome. Biochem. Mol. Med. 1995; 55: 31–37.

    Article  PubMed  CAS  Google Scholar 

  • Mifsud, A., Ramirez, S. and Yong, E.L. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J. Clin. Endocrinol. Metab. 2000; 85: 3484–3488.

    Article  PubMed  CAS  Google Scholar 

  • Modugno, F., Weissfeld, J.L., Trump, D.L., Zmuda, J.M., Shea, P., Cauley, J.A., Ferrell, R.E. Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk. Clin. Cancer Res. 2001; 7: 3092–3096.

    PubMed  CAS  Google Scholar 

  • Mononen, N., Syrjakoski, K., Matikainen, M., Tammela, T.L., Schleutker, J., Kallioniemi, O.P., Trapman, J. and Koivisto, P. A Two percent of Finnish prostate cancer patients have a germ-line mutation in the hormone-binding domain of the androgen receptor gene. Cancer Res. 2000; 60: 6479–6481.

    PubMed  CAS  Google Scholar 

  • Montgomery, J.S, Price, D.K. and Figg, W.D. The androgen receptor gene and its influence on the development and progression of prostate cancer. J. Pathol. 2001; 195: 138–146.

    Article  PubMed  CAS  Google Scholar 

  • Munoz de Toro, M.M., Maffini, M.V., Kass, L. and Luque, E.H. Proliferative activity and steroid hormone receptor status in male breast carcinoma. J. Steroid Biochem. Mol. Biol. 1998; 67: 333–339.

    Article  PubMed  CAS  Google Scholar 

  • Nam, R.K., Elhaji, Y., Krahn, M.D., Hakimi, J., Ho, M., Chu, W., Sweet, J., Ostrander, E.A. and Stanford, J.L Genetics of prostate cancer: too many loci, too few genes. Am. J. Hum. Genet. 2000; 67: 1367–1375.

    Article  Google Scholar 

  • Ostrowski, J., Florio, S.K., Denis, G.V., Suzuki, H. and Bomsztyk, K. Stimulation of p85/RING3 kinase in multiple organs after systemic administration of mitogens into mice. Oncogene 1998; 16: 1223–1227.

    Article  PubMed  CAS  Google Scholar 

  • Panz, V.R., Joffe, B.I., Spitz, L, Lindenberg, T., Farkas, A. and Haffejee, M. Tandem CAG repeats of the androgen receptor gene and prostate cancer risk in black and white men. Endocrine 2001; 15: 213–216.

    Article  PubMed  CAS  Google Scholar 

  • Platz, E.A., Giovannucci, E., Dahl, D.M., Krithivas, K., Hennekens, C.H., Brown, M, Stampfer, M.J. and Kantoff, P.W The androgen receptor gene GGN microsatellite and prostate cancer risk. Cancer Epidemiol. Biomarkers Prev. 1998; 7: 379–384.

    PubMed  CAS  Google Scholar 

  • Platz, E.A., Giovannucci, E., Brown, M., Cieluch, C., Shepard, T.F., Stampfer, M.J. and Kantoff, P.W. Amplified in breast cancer-1 glutamine repeat and prostate cancer risk. Prostate J. 2000; 2: 27–32.

    Article  Google Scholar 

  • Rebbeck, T.R., Kantoff, P.W., Krithivas, K., Neuhausen, S., Blackwood, M.A., Godwin, A.K., Daly, M.B., Narod, S.A., Garber, J.E., Lynch, H.T., Weber, B.L. and Brown, M Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat. Am. J. Hum. Genet. 1999; 64: 1371–1377.

    Article  PubMed  CAS  Google Scholar 

  • Sartor, O.,Zheng, Q. and Eastham, J.A. Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer. Urology 1999; 53: 378–380.

    Article  PubMed  CAS  Google Scholar 

  • Sawaya, M.E. and Shalita, A.R. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. J. Cutan. Med. Surg. 1998; 3: 9–15.

    PubMed  CAS  Google Scholar 

  • Spurdle, A.B., Dite, G.S., Chen, X., Mayne, C.J., Southey, M.C., Batten, L.E., Chy, H., Trute, L., McCredie, M.R., Giles, G.G., Armes, J., Venter, D.J., Hopper, J.L. and Chenevix-Trench G. Androgen receptor exon 1 CAG repeat length and breast cancer in women before age forty years. J. Natl. Cancer Inst. 1999; 91: 961–966.

    Article  PubMed  CAS  Google Scholar 

  • Spurdle, A.B., Webb, P.M., Chen, X., Martin, N.G., Giles, G.G. Hopper, J.L., and Chenevix-Trench, G.. Androgen receptor exon 1 CAG repeat length and risk of ovarian cancer. Int. J. Cancer 2000; 87: 637–643.

    Article  PubMed  CAS  Google Scholar 

  • Stanford, J.L., Just, J.J., Gibbs, M., Wicklund, K.G., Neal, C.L., Blumenstein, B.A. and Ostrander, E.A. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res. 1997; 57: 1194–1198.

    PubMed  CAS  Google Scholar 

  • Stanford, J., and Ostrander, E. Familial prostate cancer. Epidemiol. Rev. 2001; 23: 19–23.

    Article  PubMed  CAS  Google Scholar 

  • Scarpitta, A.M. and Sinagra, D. Polycystic ovary syndrome: an endocrine and metabolic disease. Gynecol. Endocrinol. 2000; 4: 392–395.

    Article  Google Scholar 

  • Toh, Y.C. Effect of neonatal castration on liver tumor induction by N-2-fluorenylacetamide in suckling BALB/c mice. Carcinogenesis 1981; 2: 1219–1221.

    Article  PubMed  CAS  Google Scholar 

  • Trachtenberg, J., Jewett, M.A. and Narod, S.A. Significance of the CAG repeat polymorphism of the androgen receptor gene in prostate cancer progression. J. Urol. 2000; 164: 567–572.

    Article  PubMed  Google Scholar 

  • Tsai, M.J. and O’Malley, B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 1994; 63: 451–486.

    Article  PubMed  CAS  Google Scholar 

  • von Eckardstein, S., Syska, A., Gromoll, J. Kamischke, A., Simoni, M. and Nieschlag, E. Inverse correlation between sperm concentration and number of androgen receptor CAG repeats in normal men. J. Clin. Endocrinol. Metab. 2001; 86: 2585–2590.

    Article  Google Scholar 

  • Vottero, A., Stratakis, C.A., Ghizzoni, L., Longui, C.A., Karl, M. and Chrousos, G.P. Androgen receptor-mediated hypersensitivity to androgens in women with nonhyperandrogenic hirsutism: skewing of X-chromosome inactivation. J. Clin. Endocrinol. Metab. 1999; 84: 1091–095.

    Article  PubMed  CAS  Google Scholar 

  • Wieacker, P.F., Knoke, I. and Jakubiczka, S Clinical and molecular aspects of androgen receptor defects. Exp. Clin. Endocrinol. Diabetes 1998; 106: 446–453.

    Article  PubMed  CAS  Google Scholar 

  • Xue, W., Irvine, R.A., Yu, M.C., Ross, R.K., Coetzee, G.A. and Ingles, S.A. Susceptibility to prostate cancer: interaction between genotypes at the androgen receptor and prostate-specific antigen loci. Cancer Res. 2000; 60: 839–841.

    PubMed  CAS  Google Scholar 

  • Yeh, S., Chang, H.C., Miyamoto, H. Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. Keio J. Med. 1999; 48: 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Yeh, S., Sampson, E.R., Lee, D.K., Kim, E., Hsu, C.L., Chen, Y.L., Chang, H.C., Altuwaijri, S., Huang, K.E. and Chang, C. Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer. J. Formo.s Med. Assoc. 2000; 99: 885–894.

    CAS  Google Scholar 

  • Yeh, S., Hu, Y.C., Rahman, M., Lin, H.K., Hsu, C.L., Ting, H.J., Kang, H.Y. and Chang, C. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proc. Natl. Acad. Sci. USA 2000; 97: 11256–11261.

    Article  PubMed  CAS  Google Scholar 

  • Yeh, S., Kang, H.Y., Miyamoto, H., Nishimura, K., Chang, H.C., Ting, H.J., Rahman M, Lin, H.K., Fujimoto, N., Hu, Y.C., Mizokami, A., Huang, K.E. and Chang, C. Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells. Endocrine 1999; 11: 195–202.

    Article  PubMed  CAS  Google Scholar 

  • Yong, E.L., Lim, L.S., Wang, Q., Mifsud, A., Lim, J., Ong, Y.C. and Sim, K.S. Androgen receptor polymorphisms and mutations in male infertility. J. Endocrinol. Invest. 2000; 23: 573–577.

    PubMed  CAS  Google Scholar 

  • Yong, E.L., Lim, J., Qi, W., Ong, V. and Mifsud, A. Molecular basis of androgen receptor diseases. Ann. Med. 2000; 32: 15–22.

    Article  PubMed  CAS  Google Scholar 

  • Yu, M.W., Yang, Y.C., Yang, S.Y., Cheng, S.W., Liaw, Y.F., Lin, S.M. and Chen, C.J. Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. J. Natl. Cancer Inst. 2000; 93: 1644–51.

    Article  Google Scholar 

  • Yu, M.W., Cheng, S.W., Lin, M.W., Yang, S.Y., Liaw, Y.F., Chang, H.C., Hsiao, T.J., Lin, S.M.,Lee, S.D., Chen, P.J., Liu, C.J. and Chen, C.J. Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. J. Natl. Cancer Inst. 2001; 92: 2023–2028.

    Article  Google Scholar 

  • Yu, H., Bharaj, B., Vassilikos, E.J., Giai, M. and Diamandis, E.P. Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer. Breast Cancer Res. Treat. 2000; 59: 153–161.

    Article  PubMed  CAS  Google Scholar 

  • Zitzmann, M., Brune, M., Kornmann, B., Gromoll, J., von Eckardstein, S., vonEckardstein, A. and Nieschlag. E. The CAG repeat polymorphism in the AR gene affects high density lipoproteincholesterol and arterial vasoreactivity. J. Clin. Endocrinol. Metab. 2001; 86: 4867–4873.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. National Cancer Institute, Bethesda, MD, 20892, USA

    Ann W. Hsing & Zoran Culig

  2. Departments of Pathology, Urology, and The Cancer Center, University of Rochester, Rochester, NY, 14642, USA

    Chawnshang Chang

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  1. Ann W. Hsing
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  2. Zoran Culig
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  1. University of Rochester Medical Center, UK

    Chawnshang Chang

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Hsing, A.W., Culig, Z., Chang, C. (2002). The Expanded Poly-Q Length Within AR and AR Coregulator AIB1 and Their Clinical Implications. In: Chang, C. (eds) Androgens and Androgen Receptor. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1161-8_9

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