Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity

  • Cynthia A. Heinlein
  • Chang Chawnshang 


The development and maintenance of the prostate is dependent on the proper functioning of the androgen receptor (AR) in response to the androgenic steroids testosterone (T) and dihydrotestosterone (DHT). In addition to androgens, paracrine and autocrine regulation of cell growth by peptide growth factors and cytokines contribute to prostate homeostasis. Unlike steroid hormones, growth factors regulate cellular responses through binding to membrane tyrosine kinase receptors. Growth factor or cytokine binding initiates a phosphorylation cascade that ultimately results in phosphorylation of transcription factors or transcription factor interacting proteins. In the prostate, AR is among the transcription factors whose activity is influenced by signal transduction cascades and disruption of the normal interaction between signal transduction and AR transactivation may contribute to the progression of prostate cancer.


Mitogen Activate Protein Kinase Hepatocyte Growth Factor Prostate Cancer Cell Focal Adhesion Kinase LNCaP Cell 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Cynthia A. Heinlein
    • 1
  • Chang Chawnshang 
    • 1
  1. 1.George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation OncologyUniversity of RochesterRochester

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