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Androgen Therapy in Nonendocrine Illnesses

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Book cover Androgens and Androgen Receptor

Abstract

This chapter presents current data regarding androgen administration in nonendocrine disorders such as critical illness, acquired immune deficiency syndrome (AIDS), renal failure, and pulmonary disease. The effects of testosterone (T) on virility and muscle strength have been recognized since ancient times. In the late 1800s, Brown-Sequard reasoned that the decreased virility and muscle mass associated with aging could potentially be reversed with T supplementation. In 1889, he reported to the Societe de Biologie in Paris a trial of self-administration of an extract from testes of dogs and guinea pig (Hoberman and Yesalis, 1995). His description of increased physical strength and intellectual energy (as well as relief from constipation and lengthened arc of his urine) triggered a burst of interest in T within the scientific community. Although Brown-Sequard’s experiments were subsequently shown to be a dramatic demonstration of placebo effect (his extraction process denatured sex steroids), the resultant research led to isolation of T by the mid 1930s. By the 1940s, analogs of T were being produced and evaluated.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology, University of Vermont Medical School, USA

    Daniel Spratt (Director, Associate Professor of Medicine)

  2. Departments of Ob/Gyn and Medicine, Maine Medical Center, Maine, USA

    Daniel Spratt (Director, Associate Professor of Medicine)

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  1. Daniel Spratt
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Editors and Affiliations

  1. University of Rochester Medical Center, UK

    Chawnshang Chang

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© 2002 Springer Science+Business Media New York

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Spratt, D. (2002). Androgen Therapy in Nonendocrine Illnesses. In: Chang, C. (eds) Androgens and Androgen Receptor. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1161-8_18

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  • DOI: https://doi.org/10.1007/978-1-4615-1161-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5422-2

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