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Androgens in Penile Development, Penile Erection, and Erectile Dysfunction

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Androgens and Androgen Receptor

Abstract

Simply stated, androgens are essential for normal penile development. However, the exact molecular mechanisms by which androgens affect the formation of the penis remain largely unknown. In this chapter, we will review the embryology of the penis and our current, but limited, understanding of the role of androgens in the development of the penis.

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References

  • Baba, K., Yajima, M., Carrier, S., Morgan, D.M., Nunes, L., Lue, T.F. and Iwamoto, T. Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis. BJU Int. 2000; 85(7): 953–958.

    Article  PubMed  CAS  Google Scholar 

  • Baskin, L.S., Sutherland, R.S., DiSandro, M.J., Hayward, S.W., Lipschutz, J. and Cunha, G.R. The effect of testosterone on androgen receptors and human penile growth. J. of Urol. 1997; 158: 1113.

    Article  CAS  Google Scholar 

  • Baskin, L.S. Hypospadias and urethral development. Journal of Urology 2000; 163: 951.

    Article  PubMed  CAS  Google Scholar 

  • Beyer,C. and Gonzalez-Mariscal, G. Effects of sex steroids on sensory and motor spinal mechanisms. Psychoneuroendocrinology 1994; 19: 517–527.

    Article  PubMed  CAS  Google Scholar 

  • George, F.W. and Peterson, K.G. 5 alpha-dihydrotestosterone formation is necessary for embryogenesis of the rat prostate. Endocrinology 1988; 122: 1159.

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez-Cadavid, N.F., Swerdloff, R.S., Lemmi, C.A. and Rajfer, J. Expression of the androgen receptor gene in rat penile tissue and cells during sexual maturation. Endocrinology 1991; 129: 1671.

    Article  PubMed  CAS  Google Scholar 

  • Graham CW, Regan JB. Blinded clinical trial of testosterone enanthate in impotent men with low or low-normal serum testosterone levels. Int. J. Impotence Res. 1992; 4: P144.

    Google Scholar 

  • Grumbach, M.M. and Conte, F.A. Disorders of Sex Differentiation. In: Williams textbook of endocrinology. Edited by Wilson, J.D., Foster, Kronenberg and Larson. Philadelphia: Saunders 1998; chapter 1303.

    Google Scholar 

  • Karadeniz, T., Topsakal, M., Ariman, A., Erton, H. and Basak, D. Judgment of color Doppler ultrasound with respect to cavernous artery occlusion pressure in dynamic infusion cavernosometry when evaluating arteriogenic impotence. Urologia Internationalis 1996; 57: 85–88.

    Article  PubMed  CAS  Google Scholar 

  • Kurzrock, E.A., Baskin, L.S., Li, Y. and Cunha, G.R. Epithelial-mesenchymal interactions in development of the mouse fetal genital tubercle. Cells Tissues Organs 1999; 164: 125.

    Article  PubMed  CAS  Google Scholar 

  • Langman, J. and Sadler, T.W. Langman’s medical embryology. Philadelphia: Lippincott Williams & Wilkins, Pages, 2000.

    Google Scholar 

  • Lee, P.A., Mazur, T., Danish, R., Amrhein, J., Blizzard, R.M., Money, J. and Migeon, C.J. Micropenis. I. Criteria, etiologies and classification. Johns Hopkins Medical Journal 1980; 146: 156.

    PubMed  CAS  Google Scholar 

  • Levy, J.B., Seay, T.M., Tindall, D.J. and Husmann, D.A The effects of androgen administration on phallic androgen receptor expression. J. of Urol. 1996; 156: 775

    Article  CAS  Google Scholar 

  • Lue, T.F. Contemporary Diagnosis and Management of Male Erectile dysfunction. Newtown, Penn. Handbooks in Health Care Co., 1999.

    Google Scholar 

  • Mills, T.M., Stopper, V.S. and Wiedmeier, V.T. Effects of castration and androgen replacement on the hemodynamics of penile erection in the rat. Biol. Reprod. 1994; 51: 234–238.

    Article  PubMed  CAS  Google Scholar 

  • Morales, A. and Heaton, J.P., Carson CC 3rd. Andropause: a misnomer for a true clinical entity. J. Urol. 2000; 163(3): 705–12.

    Article  PubMed  CAS  Google Scholar 

  • Muller, S.C., Hsieh, J.T., Lue, T.F. and Tanagho, E.A. Castration and erection. An animal study. Eur. Urol. 1988; 15(1-2): 118–24.

    PubMed  CAS  Google Scholar 

  • Mulligan, T., and Schmitt, B. Testosterone for erectile failure. J. Int. Med. 1993; 8: 517–521.

    CAS  Google Scholar 

  • Penson, D.F., Ng, C., Cai, L., Rajfer, J. and Gonzalez-Cadavid, N.F. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biology of Reproduction 1996; 55: 567–74.

    Article  PubMed  CAS  Google Scholar 

  • Prahalada, S., Tarantal, A.F., Harris, G.S., Ellsworth, K.P., Clarke, A.P., Skiles, G.L., MacKenzie, K.I., Kruk, L.F., Ablin, D.S., Cukierski, M.A., Peter, C.P., vanZwieten, M.J. and Hendrickx, A.G. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta). Teratology 1997; 55: 119.

    Article  PubMed  CAS  Google Scholar 

  • Rambeaud, J.J. Intermittent complete androgen blockade in metastatic prostate cancer. European Urology 1999; 35 Suppl 1: 32–36.

    Article  CAS  Google Scholar 

  • Reilly, CM. Stopper, V.S. Mills, T.M. Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J. Androl. 1997; 18: 26–31.

    PubMed  CAS  Google Scholar 

  • Shabsigh, R. The effects of testosterone on the cavernous tissue and erectile function. World J. Urol, 1997; 15: 21–26.

    Article  PubMed  CAS  Google Scholar 

  • Shima, H., Tsuji, M., Elfman, F. and Cunha, G.R. Development of male urogenital epithelia elicited by soluble mesenchymal factors. J. of Androl. 1995; 16: 233.

    CAS  Google Scholar 

  • Takane, K.K., Wilson, J.D. and McPhaul, M.J. Decreased levels of the androgen receptor in the mature rat phallus are associated with decreased levels of androgen receptor messenger ribonucleic acid. Endocrinology 1991; 129: 1993.

    Article  Google Scholar 

  • Traish, A.M, Park, K., Dhir, V., Kim, N.N., Moreland, R.B. and Goldstein, I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 1999; 140: 1861–1868.

    Article  PubMed  CAS  Google Scholar 

  • van der Werff, J.F., Nievelstein, R.A., Brands, E., Luijsterburg, A.J. and Vermeij-Keers, C. Normal development of the male anterior urethra. Teratology, 2000; 61: 172.

    Article  PubMed  Google Scholar 

  • Williams-Ashman, H.G. and Reddi, A.H. Differentiation of mesenchymal tissues during phallic morphogenesis with emphasis on the os penis: roles of androgens and other regulatory agents. J. of Ster. Biochem. Mol. Biol. 1991; 39: 873.

    Article  CAS  Google Scholar 

  • Zalel, Y., Pinhas-Hamiel, O., Lipitz, S., Mashiach, S. and Achiron, R. The development of the fetal penis-an in utero sonographic evaluation. Ultrasound in Obstetrics and Gynecology 2001; 17: 129.

    Article  PubMed  CAS  Google Scholar 

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Chang, J.A., Nguyen, H.T., Lue, T.F. (2002). Androgens in Penile Development, Penile Erection, and Erectile Dysfunction. In: Chang, C. (eds) Androgens and Androgen Receptor. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1161-8_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1161-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5422-2

  • Online ISBN: 978-1-4615-1161-8

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