Molecular Epidemiology of Rotavirus

  • Christian Mittelholzer
  • Lennart Svensson


Rotaviruses belong to the family of Reoviridae, genus Rotavirus, and are the most important etiologic agents of acute severe gastroenteritis in young children and animals worldwide (Kapikian et al., 1996). Rotavirus infections occur repeatedly in humans from birth to old age. Most of them are asymptomatic or are associated with only mild enteric symptoms. Infection in young children however can be accompanied by severe diarrhoea, most commonly after primary infection. Such severe rotavirus gastroenteritis may lead to a fatal outcome if not treated properly by fluid and electrolyte replacement.


Molecular Epidemiology Outer Capsid Protein Restriction Fragment Length Polymorphism Polymerase Chain Reaction Genotyping Acute Severe Gastroenteritis 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Christian Mittelholzer
    • 1
  • Lennart Svensson
    • 1
  1. 1.Department of VirologySwedish Institute for Infectious Disease ControlSolnaSweden

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