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Multivariate Analysis of Major Risk Factors and Coronary Heart Disease Risk in the Seven Countries Study

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Prevention of Coronary Heart Disease: Diet, Lifestyle and Risk Factors in the Seven Countries Study

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 243))

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Abstract

Multivariate analytical techniques in the Seven Countries Study were first made using cross-classifications compacted by the Mantel-Haenszel method (1). This used multiple cells in a cross-classification to take into account several risk factors simultaneously (each subdivided into a few classes) in relation to an outcome variable, such as mortality from CHD. Observed and expected cases were computed for a summary chi-square with one degree of freedom. Variances were calculated of the number of cases (events) in specified classes from sums of the expected and observed cases. However, cross-classification of risk factors became increasingly difficult with a greater number of risk factors, so a new approach was needed in multivariate analysis.

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Authors
  1. Alessandro Menotti
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Editors and Affiliations

  1. Director Nutrition and Consumer Safety Division, National Institute of Public Health and the Environment, P.O. Box 1, Bilthoven, 3720 BA, The Netherlands

    Daan Kromhout (Professor) (Professor)

  2. Association for Cardiac Research Cardioricerca, Via Adda 87, Rome, 00198, Italy

    Alessandro Menotti (Professor) (Professor)

  3. Division of Epidemiology, School of Public Health University of Minnesota, 1300 South Second Street, Minneapolis, MN, 55454-1015, USA

    Henry Blackburn (Mayo Professor Emeritus) (Mayo Professor Emeritus)

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Menotti, A. (2002). Multivariate Analysis of Major Risk Factors and Coronary Heart Disease Risk in the Seven Countries Study. In: Kromhout, D., Menotti, A., Blackburn, H. (eds) Prevention of Coronary Heart Disease: Diet, Lifestyle and Risk Factors in the Seven Countries Study. Developments in Cardiovascular Medicine, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1117-5_15

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  • DOI: https://doi.org/10.1007/978-1-4615-1117-5_15

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5402-4

  • Online ISBN: 978-1-4615-1117-5

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