Tumor necrosis factor-α gene promoter polymorphism in coal workers’ pneumoconiosis

  • Kyoung Ah Kim
  • Yong-Yeun Cho
  • Jung Sik Cho
  • Ki Hwa Yang
  • Woon Kyu Lee
  • Kweon-Haeng Lee
  • Yun Shin Kim
  • Young Liml
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 37)

Abstract

Tumor necrosis factor-alpha (TNF-a) is believed to play a central role in the pathogenesis of pneumoconiosis. TNF2, a polymorphism in the TNF-a gene promoter, has been associated with an increase in TNF-a production and airway inflammation. To investigate the frequency of TNF2 in patients who have coal workers’ pneumoconiosis (CWP) and to determine whether it is associated with development of a large opacity in CWP, we investigated the expression of the TNF2 allele in 80 patients who had CWP and in 54 healthy controls using restriction fragment length polymorphism (RFLP). Compared to controls (10.2%), the frequency of the TNF2 allele was greater in the CWP patients (20.6%). Furthermore, the TNF2 allele was very common in patients who had a large opacity (28.2%) in comparison with 13.4% in those with simple CWP. From these data, we suggest that the TNF2 allele is associated with the development of a large opacity in CWP. (Mol Cell Biochem 234/235: 205–209, 2002)

Key words

pneumoconiosis CWP tumor necrosis factor alpha promoter opacity TNF2 

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kyoung Ah Kim
    • 1
  • Yong-Yeun Cho
    • 2
  • Jung Sik Cho
    • 2
  • Ki Hwa Yang
    • 2
  • Woon Kyu Lee
    • 3
  • Kweon-Haeng Lee
    • 3
  • Yun Shin Kim
    • 4
  • Young Liml
    • 1
  1. 1.Department of Occupational and Environmental MedicineSt. Mary’s Hospital, The Catholic University of KoreaSeoulKorea
  2. 2.Department of General ToxicologyKorea Institute of Toxicological Research, Korea Food and Drug AdministrationSeoulKorea
  3. 3.Department of PharmacologyCollege of Medicine, The Catholic University of Korea;SeoulKorea
  4. 4.Department of Industrial MedicineCollege of Medicine, Hanyang UniversitySeoulKorea

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