Abstract
The health of joint tissue is a reflection of the health of bone and cartilage and the tissues that make up these organs including the contributing Type I and Type II collagens. These tissues may respond not only to ovarian and growth hormone stimulation, they also may be linked to other biological responses including reaction to oxidation and cytokine release. It is still an open question as to whether the menopausal transition impacts joint health. It is the purpose of this presentation to identify the potential for a menopause relationship to influence bones and other tissues of the joint and consider how this is related to osteoporosis and osteoarthritis.
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References
Consensus Development Conference Statement. Prophylaxis and treatment of osteoporosis. J Am Med Assoc 1991; 90: 107–10.
NIH Consensus development conference statement. Proceedings of the Osteoporosis Prevention, Diagnosis and Therapy Conference 2000; Mar 27–29.
Foss MVL, Byers PD. Bone density, osteoarthritis of the hip, and fractures of the upper end of the femur. Ann Rheum Dis 1972; 13: 259–64.
Sowers MF, Lachance L, Jamadar D, Hochberg M, Crutchfield M, Jannausch ML. The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in preand peri-menopausal women. Arth Rheum 1999; 42: 483–89.
Sowers MF. Estrogens and osteoarthritis; hormone replacement, menopause, and aging. In: Lobo RA, Kelsey J, Marcus R, editors. Menopause: Biology and pathobiology San Diego, CA: Academic Press, 2000: 535–43.
Sowers MF, Lachance L, Hochberg M, Jamadar D. Prevalence of radiographically defined osteoarthritis of the hand and knee in a population of pre and perimenopausal women. Osteoarthritis Cartilage 2000; 8: 69–77.
Smith QT, Allison DJ. Changes of collagen content in skin, femur and uterus of 17β-estradiol benzoate-treated rats. Endocrinology 1966; 79: 486–92.
Beldekas JC, Smith B, Gerstenfeld LC, Sonenshein GE, Franzblau C.Effects of 17 β-estradiol on the biosynthesis of collagen in cultured bovine aortic smooth muscle cells. Biochemistry 1981; 20: 2162–67
Hu SK, Mitcho YL, Rath NC. Effect of estradiol on interleukin 1 synthesis by macrophages. Int J Immunopharmacol 1988; 10: 247–52.
Tsai CL, Liu TK. Osteoarthritis in women: Its relationship to estrogen and current trends. Life Sci 1992; 50: 1737–44
Sheridan PJ, Aufdemorte TB, Holt GR, Gates GA. Cartilage of the baboon contains estrogen receptors. Rheumatol Int 1985; 5: 279–81.
Young PCM, Stack MT. Estrogen and glucocorticoid receptors in adult canine articular cartilage. Arthrit Rheum 1982; 25: 568–73.
Rosner IA, Manni A, Malemud CJ, Boja B, and Moskowitz KW. Estrogen receptors in articular chondrocytes. Biochem Biophys Res Commun 1982; 10: 1378–82.
Kan KW, Cruess RL, Posner BI, Guyda HJ, Solomon S. Hormone receptors in the epiphysial cartilage J Endocrinol 1984; 103: 125–31.
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Sowers, M. (2002). The Role of Menopause in Bone and Joint Health: Implications for Osteoarthritis and Osteoporosis. In: Lobo, R.A., Crosignani, P.G., Paoletti, R., Bruschi, F. (eds) Women’s Health and Menopause. Medical Science Symposia Series, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1061-1_6
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DOI: https://doi.org/10.1007/978-1-4615-1061-1_6
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