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Paraoxonase (PON1) in Health and Disease pp 185–195Cite as

PON1 in Other Diseases

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Abstract

HDL-associated paraoxonase (PON1) hydrolyses proinflammatory oxidized lipids, therefore blunting the inflammatory response. Increased oxidative stress leading to inflammation is involved in the etiology of several diseases, such as diabetes mellitus, atherosclerosis and a number of neurological disorders. Low PON1 activity is a typical feature of diabetes implicating the enzyme in the etiology of the disease and its complications. PON1 and PON2 polymorphisms have been associated with the presence of several diabetic complications such as CVD, nephropathy and retinopathy and glycemic control a major risk factor for CVD in diabetes. PON1 polymorphisms have also been associated with the presence of cerebrovascular disease and may be associated with the presence of other neurological disorders such as Parkinson’s disease. Low PON1 may also be associated with the development of Gulf War Syndrome. These findings indicate a wider role for PON1 in disease development in addition to its more established roles in protecting against organophosphate intoxication and the development of atherosclerosis. PON2 and PON3, although little studied, may have similarly important roles.

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Author information

Authors and Affiliations

  1. Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK

    Bharti Mackness, Paul N. Durrington & Michael I. Mackness

Authors
  1. Bharti Mackness
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  2. Paul N. Durrington
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  3. Michael I. Mackness
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Editor information

Editors and Affiliations

  1. Department of Environmental Health, University of Washington, Seattle, WA, 98195-4695, USA

    Lucio G. Costa

  2. Department of Pharmacology and Physiology, University of Roma “La Sapienza”, Roma, Italy

    Lucio G. Costa

  3. Departments of Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, 98195-7720, USA

    Clement E. Furlong

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© 2002 Springer Science+Business Media New York

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Mackness, B., Durrington, P.N., Mackness, M.I. (2002). PON1 in Other Diseases. In: Costa, L.G., Furlong, C.E. (eds) Paraoxonase (PON1) in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1027-7_9

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  • DOI: https://doi.org/10.1007/978-1-4615-1027-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5358-4

  • Online ISBN: 978-1-4615-1027-7

  • eBook Packages: Springer Book Archive

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