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Paraoxonase (PON1) in Health and Disease pp 137–163Cite as

PON1 in Different Species

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Abstract

Paraoxonase (PON1) hydrolyzes a great number of toxic organophosphorus compounds (OP) and uncharged esters of acetic acid and aromatic alcohols. No selective substrate and no standard assay method exist for PON1. Therefore strong definition criteria have to be applied to distinguish PON1 from other OP-detoxicating enzymes. Activity ratios of phenylacetate vs. OP, EDTA-inhibition, calcium-stimulation and resistance to covalent OP-inhibition are the criteria to identify PON1. PON1 is exclusively found in mammals and is synthesized by the liver. Plasma PON1 is bound to α-lipoproteins. Different mammalian species show great variations concerning their mean as well as their individual PON 1-activities. PON-activity in vivo is influenced by hormones and by diet.

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  1. Göttingen, Institut für Biochemie und Molekulare Zellbiologie, Medizinische Fakultät, Universität Goettingen, D-37073, Goettingen, Germany

    Ronald Zech & Jörg M. Chemnitius

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  1. Ronald Zech
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  2. Jörg M. Chemnitius
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  1. Department of Environmental Health, University of Washington, Seattle, WA, 98195-4695, USA

    Lucio G. Costa

  2. Department of Pharmacology and Physiology, University of Roma “La Sapienza”, Roma, Italy

    Lucio G. Costa

  3. Departments of Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, 98195-7720, USA

    Clement E. Furlong

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Zech, R., Chemnitius, J.M. (2002). PON1 in Different Species. In: Costa, L.G., Furlong, C.E. (eds) Paraoxonase (PON1) in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1027-7_7

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  • DOI: https://doi.org/10.1007/978-1-4615-1027-7_7

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