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Paraoxonase (PON1) in Health and Disease pp 79–92Cite as

The Role of Paraoxonase in Lipid Metabolism

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Abstract

High-density lipoprotein (HDL) has been known for many years to protect against the development of coronary heart disease, although the exact mechanism is unclear. Great attention has been focused on the central role of HDL in reverse cholesterol transport. Recently, however, the role of HDL in preventing the oxidation of low-density lipoprotein (LDL) has received much attention. The oxidation of LDL is central to current theories on the initiation and progression of atherosclerosis. HDL can retard the oxidation of LDL. Central to this action of HDL is PON1 (paraoxonase) which hydrolyzes oxidized-phospholipids and cholesteryl-esters on LDL, HDL and in atherosclerotic plaques, thus retarding oxidation and attenuating the inflammatory process of atherosclerosis.

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Authors and Affiliations

  1. University Department of Medicine, Manchester Royal Infirmary Oxford Road, Manchester, M13 9WL, UK

    Michael I. Mackness, Paul N. Durrington & Bharti Mackness

Authors
  1. Michael I. Mackness
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  2. Paul N. Durrington
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  3. Bharti Mackness
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Editors and Affiliations

  1. Department of Environmental Health, University of Washington, Seattle, WA, 98195-4695, USA

    Lucio G. Costa

  2. Department of Pharmacology and Physiology, University of Roma “La Sapienza”, Roma, Italy

    Lucio G. Costa

  3. Departments of Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, 98195-7720, USA

    Clement E. Furlong

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© 2002 Springer Science+Business Media New York

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Mackness, M.I., Durrington, P.N., Mackness, B. (2002). The Role of Paraoxonase in Lipid Metabolism. In: Costa, L.G., Furlong, C.E. (eds) Paraoxonase (PON1) in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1027-7_4

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  • DOI: https://doi.org/10.1007/978-1-4615-1027-7_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5358-4

  • Online ISBN: 978-1-4615-1027-7

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