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Steroid Hormones and Cell Cycle Regulation pp 147–171Cite as

Vitamin D Regulation of Cell Cycle and Differentiation in Myeloid Cells

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Abstract

The fat-soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3[1,25(OH)2D3], is a major regulator of mineral homeostasis and bone formation remodeling (Feldman et al. 1997). Perhaps surprisingly, this ligand can also elicit potent growth inhibitory and differentiation effects on a variety of cell types, including myeloid cells. 1,25(OH)2D3 transduces its signal directly through a regulable, DNA-binding transcription factor, the vitamin D3 receptor (VDR), which is a member of a large superfamily collectively known as nuclear hormone receptors. Thus, vitamin D3-inducible effects on cell growth and differentiation are initiated through the direct activation or repression of target genes by VDR. The identities of such genes, however, have remained elusive until recently.

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Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center and Sloan-Kettering Division, NY, 10021, USA

    V. Carrie Bromleigh & Leonard P. Freedman

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  1. V. Carrie Bromleigh
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  2. Leonard P. Freedman
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  1. University of Miami School of Medicine, USA

    Kerry L. Burnstein

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Bromleigh, V.C., Freedman, L.P. (2002). Vitamin D Regulation of Cell Cycle and Differentiation in Myeloid Cells. In: Burnstein, K.L. (eds) Steroid Hormones and Cell Cycle Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0965-3_9

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  • DOI: https://doi.org/10.1007/978-1-4615-0965-3_9

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