Abstract
Androgen signaling is a key determinant in the development and maintenance of the male reproductive system, and also plays a critical role in associated pathologies such as prostate cancer. The androgen receptor (AR), a member of the steroid receptor (SR) subgroup of the nuclear receptor (NR) superfamily, modulates gene expression in response to androgens in target tissues including the brain, liver, pituitary gland and prostate (Chang et al., 1995). SRs have a conserved domain structure that includes ligand-independent and ligand-dependent activation functions (AF-1 & AF-2) and a general mechanism of action (White et al., 1998). In response to ligands, SRs undergo a conformational change within the ligand-binding domain (LBD), dissociate from chaperone proteins and form homodimers (White et al., 1998). The activated receptor dimer then enhances target gene expression from response elements within the target gene promoter by modulating the activity of the general transcription machinery (White et al., 1998).
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Sampson, E.R. et al. (2002). Interaction of Cell Cycle Regulatory Proteins with the Androgen Receptor. In: Burnstein, K.L. (eds) Steroid Hormones and Cell Cycle Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0965-3_13
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DOI: https://doi.org/10.1007/978-1-4615-0965-3_13
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