Leishmania pp 169-190 | Cite as

Anti-Leishmania Vaccine

  • Antonio Campos-Neto
Part of the World Class Parasites book series (WCPA, volume 4)


Vaccination against cutaneous leishmaniasis has been used or tested in humans for approximately 75 years. In the Old World, deliberated inoculation of virulent organisms from the pus of an active lesion (probably L. major) in non-exposed areas of the body is an ancient practice. Promastigotes of L. major grown in culture was first used in Russia in 1937 by Lawrow and Dubowokoj as a means to effectively induce protection against natural infection (1). More recently, standardized inoculum of culture promastigotes were developed by Israeli scientists and used in several trials (2). This process known as leishmanization is still used in some countries, notably Uzbekistan (3). Leishmanization has been proven to be efficacious against Old World cutaneous leishmaniasis (4). However, several basic and logistic problems have precluded the widespread use of this procedure to prevent cutaneous leishmaniasis. Some of these problems include: 1. Difficulty in standardizing the virulence of the vaccine; and 2. Side effects such as the severe and long lasting lesions that occur in many vaccinated individuals (5). Moreover, there are no evidences of the effectiveness of leishmanization against either New World tegumental leishmaniasis or against human visceral leishmaniasis.


Visceral Leishmaniasis Cutaneous Leishmaniasis Antigen Delivery Excellent Protection Leishmania Major Infection 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Antonio Campos-Neto
    • 1
  1. 1.Infectious Disease Research InstituteSeattleUSA

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