Abstract
Stimulation of monocytes/macrophages with IFN-g, derived from activated T cells, results in the release of elevated concentrations of neopterin and 7,8-dihydroneopterin by activation of GTP cyclohydrolase I (1,2). In patients, he production of neopterin hereby closely correlates with IFN-g concentrations and the activation of cell mediated immunity (3). Neopterin is elevated during virus infections including HIV, autoimmune disorders such as systemic lupus erythematosus (SLE) and in certain types of cancers. Formation of neopterin correlates with the ability of the cells to form hydrogen peroxide (4) suggesting that elevated neopterin indicates an increase in production of oxidizing substances. Recently a number of papers presented evidence that neopterin and its reduced forms have impact on redox-regulated processes (5). Involvement of oxidative stress in the pteridine-mediated apoptosis is found in several cell lines, but signalling pathways activated in this cascade remain unclear.
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Enzinger, C. et al. (2002). Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines. In: Milstien, S., Kapatos, G., Levine, R.A., Shane, B. (eds) Chemistry and Biology of Pteridines and Folates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0945-5_63
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DOI: https://doi.org/10.1007/978-1-4615-0945-5_63
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